Epidemiological Dynamics of Extended-Spectrum β-Lactamase- or AmpC β-Lactamase-Producing Escherichia coli Screened in Apparently Healthy Chickens in Uganda

被引:5
|
作者
Kakooza, Steven [1 ,2 ,3 ]
Munyiirwa, Damien [1 ]
Ssajjakambwe, Paul [4 ]
Kayaga, Edrine [1 ]
Tayebwa, Dickson Stuart [1 ]
Ndoboli, Dickson [1 ]
Basemera, Loreen [1 ]
Nabatta, Esther [5 ]
Tumwebaze, Maria Agnes [1 ]
Kaneene, John Baligwamunsi [6 ]
机构
[1] Makerere Univ, Coll Vet Med Anim Resources & Biosecur, Cent Diagnost Lab, Kampala, Uganda
[2] Vet Sans Frontieres Germany, Kampala, Uganda
[3] Novel Minds Sci Plexus, Kampala, Uganda
[4] Makerere Univ, Coll Vet Med Anim Resources & Biosecur, Dept Vet Pharm Clin & Comparat Med, Kampala, Uganda
[5] Makerere Univ, Infect Dis Inst, Coll Hlth Sci, Kampala, Uganda
[6] Michigan State Univ, Ctr Comparat Epidemiol, 736 Wilson Rd,Room A-109, E Lansing, MI 48824 USA
来源
SCIENTIFICA | 2021年 / 2021卷
关键词
ANTIMICROBIAL RESISTANCE; ENTEROBACTERIACEAE; SALMONELLA; POULTRY;
D O I
10.1155/2021/3258059
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The dynamics of extended-spectrum beta-lactamase- (ESBL-) and AmpC beta-lactamase-producing bacteria (which are deadly groups of antimicrobial-resistant bacteria) have not been well understood in developing countries. This raises major concerns to antimicrobial resistance (AMR) control. We investigated the prevalence and factors linked to the fecal carriage of ESBL- or AmpC-producing Escherichia coli (ESBL-/AmpC-EC) in commercial chickens. Cloacal swabs from 400 birds were sampled and submitted to the Central Diagnostic Laboratory for ESBL-/AmpC-EC screening by culture methods using MacConkey agar supplemented with cefotaxime. Epidemiological data were collected using a structured questionnaire and plausible risk factor analyses prepared by R software using X-2 test and logistic regression modeling. Results showed that the prevalence of ESBL-/AmpC-EC was 17.5%. Univariable screening hypothesized that carriage was probably influenced by a type of commercial chicken, geographical location, age group, flock size, and housing system (p<0.05). Modeling exposed that broiler birds were at a higher risk of being ESBL-/AmpC-EC carriers (COR = 9.82, CI = 3.85-25.07). Birds from Wakiso Town Council (COR = 4.89, CI = 2.04-11.72) and flocks of 700-1200 birds were also at a higher risk of harboring ESBL-/AmpC-EC (COR = 2.41, CI = 1.11-5.23). Birds aged 4 months and below were more susceptible to ESBL-/AmpC-EC carriage compared with those aged 1 month and below being 6.33 times (CI = 1.65-24.35) likely to be carriers. The occurrence of ESBL-/AmpC-EC in flocks suggests possible treatment failures while managing colibacillosis. Consequently, injudicious antimicrobial use should be replaced with an accurate diagnosis by bacterial culture and sensitivity testing so as to circumvent AMR emergence, spread, and associated losses.
引用
收藏
页数:6
相关论文
共 50 条
  • [1] Detection of Extended-spectrum β-lactamase and AmpC β-lactamase Producing Escherichia coli Isolates from Chickens
    Basaran Kahraman, Beren
    Diren Sigirci, Belgi
    Celik, Baran
    Gumus, Berna
    Metiner, Kemal
    Adiguzel, M. Cemal
    Bagcigil, A. Funda
    Ikiz, Serkan
    Ozgur, N. Yakut
    Ak, Seyyal
    [J]. KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, 2016, 22 (04) : 591 - 596
  • [2] Extended-spectrum β-lactamase-producing Escherichia coli
    Sloth, Louise B.
    Hargreaves, Sally
    Nellums, Laura B.
    Nielsen, Rikke T.
    Norredam, Marie
    [J]. LANCET INFECTIOUS DISEASES, 2020, 20 (04): : 405 - 405
  • [3] Prevalence and characterization of extended-spectrum β-lactamase- and AmpC β-lactamase-producing Escherichia coli: results of the CANWARD 2007-2009 study
    Simner, Patricia J.
    Zhanel, George G.
    Pitout, Johann
    Tailor, Franil
    McCracken, Melissa
    Mulvey, Michael R.
    Lagace-Wiens, Philippe R. S.
    Adam, Heather J.
    Hoban, Daryl J.
    [J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2011, 69 (03) : 326 - 334
  • [4] Extended-Spectrum β-Lactamase- and AmpC-Producing Enterobacteria in Healthy Broiler Chickens, Germany
    Reich, Felix
    Atanassova, Viktoria
    Klein, Guenter
    [J]. EMERGING INFECTIOUS DISEASES, 2013, 19 (08) : 1253 - 1259
  • [5] Wild Boars Carry Extended-Spectrum β-Lactamase- and AmpC-Producing Escherichia coli
    Holtmann, Anna R.
    Meemken, Diana
    Mueller, Anja
    Seinige, Diana
    Buettner, Kathrin
    Failing, Klaus
    Kehrenberg, Corinna
    [J]. MICROORGANISMS, 2021, 9 (02) : 1 - 13
  • [6] Extended-spectrum-β-lactamase- and AmpC-β-lactamase-producing Escherichia coli in Dutch broilers and broiler farmers
    Dierikx, Cindy
    van der Goot, Jeanet
    Fabri, Teun
    van Essen-Zandbergen, Alieda
    Smith, Hilde
    Mevius, Dik
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2013, 68 (01) : 60 - 67
  • [7] Molecular Characterization of Fecal Extended-Spectrum β-Lactamase- and AmpC β-Lactamase-Producing Escherichia coli From Healthy Companion Animals and Cohabiting Humans in South Korea
    Hong, Jun Sung
    Song, Wonkeun
    Park, Hee-Myung
    Oh, Jae-Young
    Chae, Jong-Chan
    Jeong, Seri
    Jeong, Seok Hoon
    [J]. FRONTIERS IN MICROBIOLOGY, 2020, 11
  • [8] Transmission dynamics of extended-spectrum β-lactamase and AmpC β-lactamase-producing Escherichia coli in a broiler flock without antibiotic use
    Huijbers, Patricia M. C.
    Graat, Elisabeth A. M.
    van Hoek, Angela H. A. M.
    Veenman, Christiaan
    de Jong, Mart C. M.
    van Duijkeren, Engeline
    [J]. PREVENTIVE VETERINARY MEDICINE, 2016, 131 : 12 - 19
  • [9] Extended-Spectrum β-Lactamase and AmpC β-Lactamase-Producing Escherichia coli Isolates from Chickens Raised in Small Flocks in Ontario, Canada
    Ghosh, Kazal K.
    Lebert, Lindsey A.
    McEwen, Scott A.
    Reid-Smith, Richard J.
    Deckert, Anne E.
    Agunos, Agnes
    Reid, M. Alexandra
    Rubin, Joseph E.
    [J]. MICROBIAL DRUG RESISTANCE, 2019, 25 (08) : 1250 - 1256
  • [10] Prevalence of extended-spectrum and AmpC β-lactamase-producing Escherichia coli in Dutch dairy herds
    Heuvelink, Annet E.
    Gonggrijp, Maaike A.
    Buter, Rianne G. J.
    ter Bogt-Kappert, Carlijn C.
    van Schaik, Gerdien
    Velthuis, Annet G. J.
    Lam, Theo J. G. M.
    [J]. VETERINARY MICROBIOLOGY, 2019, 232 : 58 - 64