Peptide-peptoid hybrids based on (1-11)-parathyroid hormone analogs

被引：4
|
作者：
Caporale, A. [1 ]
Schievano, E. [1 ]
Peggion, E. [1 ]
机构：
[1] Univ Padua, Inst Biomol Chem, CNR, Dept Chem Sci, I-35131 Padua, Italy
来源：
JOURNAL OF PEPTIDE SCIENCE | 2010年 / 16卷 / 09期
关键词：
N-substituted glycine; peptidomimetics; PTH analogs; conformation; bioactivities; N-SUBSTITUTED GLYCINES; PARATHYROID-HORMONE; PTH(1-11) ANALOGS; IDENTIFICATION; DRUG; LIBRARY; DESIGN; MINIMIZATION; AGONISTS; SPECTRA;
D O I：
10.1002/psc.1265
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of peptide-peptoid hybrids, containing N-substituted glycines, were synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH2 (Har = Homoarginine) as the parent parathyroid hormone (1-11) analog. The compounds were pharmacologically characterized in their agonistic activity at the parathyroid hormone 1 receptor. Copyright (c) 2010 European Peptide Society and John Wiley & Sons, Ltd.
引用
收藏
页码：480 / 485
页数：6
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