Anti-androgenic activity of Myricae Cortex -: Isolation of active constituents from bark of Myrica rubra

被引：45
|
作者：
Matsuda, H
Yamazaki, M
Matsuo, K
Asanuma, Y
Kubo, M
机构：
[1] Kinki Univ, Fac Pharmaceut Sci, Higashiosaka, Osaka 5778502, Japan
[2] Daiichi Pharmaceut Co Ltd, Chuo Ku, Tokyo 1038234, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2001年 / 24卷 / 03期
关键词：
Myrica rubra; testosterone; 5; alpha-reductase; anti-androgenic activity; hair regrowth;
D O I：
10.1248/bpb.24.259
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aqueous ethanol extract of Myricae Cortex (bark of Myrica rubra SIEB, et Zucc., Myrieaceae) showed in vitro testosterone 5 alpha -reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. Three constituents, myricanone, myricanol, and myricetin were identified as the main active principles.
引用
收藏
页码：259 / 263
页数：5
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    Hirano, Kazuyuki
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