Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

被引：114

作者：

Khan, Khadija ^{[1
,2
]}

Karim, Farina ^{[1
,2
]}

Ganga, Yashica ^{[1
]}

Bernstein, Mallory ^{[1
]}

Jule, Zesuliwe ^{[1
]}

Reedoy, Kajal ^{[1
]}

Cele, Sandile ^{[1
,2
]}

Lustig, Gila ^{[3
]}

Amoako, Daniel ^{[4
,5
]}

Wolter, Nicole ^{[4
,6
]}

Samsunder, Natasha ^{[3
]}

Sivro, Aida ^{[3
,7
]}

San, James Emmanuel ^{[8
]}

Giandhari, Jennifer ^{[8
]}

Tegally, Houriiyah ^{[8
,9
]}

Pillay, Sureshnee ^{[8
]}

Naidoo, Yeshnee ^{[8
]}

Mazibuko, Matilda ^{[1
]}

Miya, Yoliswa ^{[1
]}

Ngcobo, Nokuthula ^{[1
]}

Manickchund, Nithendra ^{[10
]}

Magula, Nombulelo ^{[11
]}

Karim, Quarraisha Abdool ^{[3
,12
]}

von Gottberg, Anne ^{[4
,6
]}

Karim, Salim S. Abdool ^{[3
,12
]}

Hanekom, Willem ^{[1
,13
]}

Gosnell, Bernadett, I ^{[10
]}

Lessells, Richard J. ^{[8
]}

de Oliveira, Tulio ^{[8
,9
,14
]}

Moosa, Mahomed-Yunus S. ^{[10
]}

Sigal, Alex ^{[1
,2
,3
,15
]}

机构：

[1] Africa Hlth Res Inst, Durban, South Africa

[2] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Durban, South Africa

[3] Ctr AIDS Programme Res South Africa, Durban, South Africa

[4] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Johannesburg, South Africa

[5] Univ KwaZulu Natal, Coll Hlth Sci, Sch Hlth Sci, Durban, South Africa

[6] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa

[7] Univ KwaZulu Natal, Dept Med Microbiol, Durban, South Africa

[8] KwaZulu Natal Res Innovat & Sequencing Platform, Durban, South Africa

[9] Stellenbosch Univ, Ctr Epidem Response & Innovat CERI, Sch Data Sci & Computat Thinking, Stellenbosch, South Africa

[10] Univ KwaZulu Natal, Nelson R Mandela Sch Clin Med, Dept Infect Dis, Durban, South Africa

[11] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Div Internal Med, Durban, South Africa

[12] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA

[13] UCL, Div Infect & Immun, London, England

[14] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[15] Max Planck Inst Infect Biol, Berlin, Germany

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

SARS-COV-2; OMICRON;

D O I：

10.1038/s41467-022-32396-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SARS-CoV-2 Omicron (B.1.1.529) BA.4 and BA.5 sub-lineages, first detected in South Africa, have changes relative to Omicron BA.1 including substitutions in the spike receptor binding domain. Here we isolated live BA.4 and BA.5 viruses and measured BA.4/BA.5 neutralization elicited by BA.1 infection either in the absence or presence of previous vaccination as well as from vaccination without BA.1 infection. In BA.1-infected unvaccinated individuals, neutralization relative to BA.1 declines 7.6-fold for BA.4 and 7.5-fold for BA.5. In vaccinated individuals with subsequent BA.1 infection, neutralization relative to BA.1 decreases 3.2-fold for BA.4 and 2.6-fold for BA.5. The fold-drop versus ancestral virus neutralization in this group is 4.0-fold for BA.1, 12.9-fold for BA.4, and 10.3-fold for BA.5. In contrast, BA.4/BA.5 escape is similar to BA.1 in the absence of BA.1 elicited immunity: fold-drop relative to ancestral virus neutralization is 19.8-fold for BA.1, 19.6-fold for BA.4, and 20.9-fold for BA.5. These results show considerable escape of BA.4/BA.5 from BA.1 elicited immunity which is moderated with vaccination and may indicate that BA.4/BA.5 may have the strongest selective advantage in evading neutralization relative to BA.1 in unvaccinated, BA.1 infected individuals. Emerging SARS-CoV-2 Omicron sub-lineages BA.4 and BA.5 raise concerns about potential immune evasion. Here, Khan et al. show that both BA.4 and BA.5 are able to escape immune response induced by prior BA.1 infection, but that this effect is less pronounced in vaccinated individuals.

引用

页数：7

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