The Recombinant Hepatitis B Surface Antigen Vaccine in Persons With HIV: Is Seroconversion Sufficient for Long-term Protection?

被引：11
|
作者：
Powis, Jeff E. [1 ]
Raboud, Janet [2 ]
Ostrowski, Mario [1 ]
Loutfy, Mona R. [1 ]
Kovacs, Colin [1 ]
Walmsley, Sharon L. [1 ]
机构：
[1] Univ Toronto, Dept Med, Toronto, ON M5S 1A1, Canada
[2] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON M5S 1A1, Canada
来源：
JOURNAL OF INFECTIOUS DISEASES | 2012年 / 205卷 / 10期
关键词：
ACTIVE ANTIRETROVIRAL THERAPY; INFECTED INDIVIDUALS; HOMOSEXUAL MEN; VIRUS; INJECTIONS; ANTIBODY; MEMORY; NUMBER; RISK; LOAD;
D O I：
10.1093/infdis/jis243
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A cohort of human immunodeficiency virus (HIV)-infected individuals with documented vaccine-induced hepatitis B surface antibody (HBsAb) seroconversion was evaluated retrospectively to determine factors associated with loss of protective levels of HBsAb. After a median follow-up of 43 months, 111 of the 152 participants (73%) maintained protective levels of HBsAb. HIV RNA suppression at vaccination was associated with persistence of protective levels of HBsAb (odds ratio, 3.83; P < .01). Booster doses were provided for those with loss of protective antibody levels, and hepatitis B virus-specific immune memory, as evaluated with T-cell proliferation assays, was poor despite the observation that boosters successfully reinduced protective levels of HBsAb.
引用
收藏
页码：1534 / 1538
页数：5
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