Robust, efficient, and orthogonal synthesis of dendrimers via thiol-ene "Click" chemistry

被引：697
|
作者：
Killops, Kato L. [1 ,2 ]
Campos, Luis M. [1 ,2 ]
Hawker, Craig J. [1 ,2 ]
机构：
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Dept Mat, Santa Barbara, CA 93106 USA
[2] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 15期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1021/ja8006325
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Dendrimers up to the fourth generation were successfully prepared via the divergent growth strategy using a combination of thiol-ene "click" chemistry and traditional esterification reactions. The thiol-ene reactions were conducted under solvent-free, ambient conditions at room temperature by irradiating with UV light. The fourth-generation dendrimers were subsequently functionalized with carboxylic acid, pyrene, and Fmoc-protected cysteine moieties via thiol-ene reactions.
引用
收藏
页码：5062 / +
页数：4
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