Infectious Complications of Pancreatic Islet Transplantation: Clinical Experience and Unanswered Questions

被引：2
|
作者：
Pouch, Stephanie M. [1 ]
机构：
[1] Ohio State Univ, Wexner Med Ctr, Div Infect Dis, Transplant Infect Dis Serv, Columbus, OH 43210 USA
来源：
CURRENT INFECTIOUS DISEASE REPORTS | 2015年 / 17卷 / 05期
关键词：
Pancreatic islet transplantation; Infection; Microbial contamination; Cytomegalovirus (CMV); Xenotransplantation; TYPE-1; DIABETES-MELLITUS; PORCINE ENDOGENOUS RETROVIRUS; CYTOMEGALOVIRUS TRANSMISSION; MICROBIAL-CONTAMINATION; NO EVIDENCE; FOLLOW-UP; SURVEILLANCE; RECIPIENTS; XENOTRANSPLANTATION; IMMUNOSUPPRESSION;
D O I：
10.1007/s11908-015-0482-9
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Pancreatic islet transplantation is an evolving treatment modality for type I diabetes mellitus. While the field has advanced significantly over the course of the past three decades, our understanding of the infectious complications of pancreatic islet transplantation remains quite limited. This review aims to describe the current literature relating to infectious complications of pancreatic islet transplantation, including the role of microbiologically contaminated islet preparations in disease pathogenesis, our current understanding of the epidemiology and outcomes of cytomegalovirus and other infectious complications of pancreatic islet transplantation, and infectious concerns related to the use of porcine pancreatic islet cell xenografts. This review also highlights unanswered clinical questions and suggests areas of future research to mitigate infectious complications in recipients of islet transplantation.
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页码：1 / 6
页数：6
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