SYNTHESIS AND CHARACTERIZATION OF ACRYLIC BEADS OBTAINED BY SUSPENSION POLYMERIZATION PROCESS FOR USE AS PHARMACEUTICAL EXCIPIENT FOR DIRECT COMPRESSION

被引：1

作者：

Oliveira Villanova, Janaina Cecilia ^{[1
]}

Lima, Tadeu Henrique ^{[2
]}

Patricio, Patricia Santiago ^{[3
]}

Pereira, Fabiano Vargas ^{[4
]}

Ayres, Eliane ^{[5
]}

机构：

[1] Univ Mogi das Cruzes, Fac Farm, BR-05305000 Sao Paulo, Brazil

[2] Univ Fed Minas Gerais, Escola Engn, Dept Engn Met & Minas, Belo Horizonte, MG, Brazil

[3] Ctr Fed Educ Tecnol Minas Gerais, Dept Quim, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Dept Quim, Belo Horizonte, MG, Brazil

[5] Univ Estadual Minas Gerais, Escola Design, Dept Mat Tecnol & Proc, Belo Horizonte, MG, Brazil

来源：

QUIMICA NOVA | 2012年 / 35卷 / 01期

关键词：

suspension polymerization; stabilizers agents; acrylic pharmaceutical excipients; PARTICLE-SIZE DISTRIBUTION; LATEX-PARTICLES; DRUG-DELIVERY; RELEASE; PREDICTION; THEOPHYLLINE; INTERFACE; POLYMERS;

D O I：

10.1590/S0100-40422012000100023

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

SYNTHESIS AND CHARACTERIZATION OF ACRYLIC BEADS OBTAINED BY SUSPENSION POLYMERIZATION PROCESS FOR USE AS PHARMACEUTICAL EXCIPIENT FOR DIRECT COMPRESSION. One of the difficulties reported for the suspension polymerization is control the size and granulometry of beads. The purpose of this work was to evaluate the use of cellulose nanowhiskers and mesoporous silica as stabilizers to reduce the size and the particle distribution. To monitor polymerization process was used FTIR-ATR spectroscopy. The morphology was analyzed by scanning electron microscopy. The particle size distribution was characterised using a CILAS granulometer. Thermal stability was studied by thermogravimetric analysis. The results indicated that cellulose nanowhiskers may provide stabilization and increase the thermal stability of the beads in contrast to mesoporous silica.

引用

页码：124 / 131

页数：8

共 7 条

[1] Pharmaceutical acrylic beads obtained by suspension polymerization containing cellulose nanowhiskers as excipient for drug delivery
Villanova, J. C. O.
Ayres, E.
Carvalho, S. M.
Patricio, P. S.
Pereira, F. V.
Orefice, R. L.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 42 (04) : 406 - 415
[2] Characterization of a novel hydroxypropyl methylcellulose (HPMC) direct compression grade excipient for pharmaceutical tablets
Allenspach, Carl
Timmins, Peter
Sharif, Shasad
Minko, Tamara
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 583
[3] Synthesis and characterization of cross-linked epoxy resin beads by suspension polymerization technique
Arjun Singh
Priyanka Singla
Subash Chandra Sahoo
Pramod Kumar Soni
Journal of Polymer Research, 2020, 27
[4] Synthesis and characterization of cross-linked epoxy resin beads by suspension polymerization technique
Singh, Arjun
Singla, Priyanka
Sahoo, Subash Chandra
Soni, Pramod Kumar
JOURNAL OF POLYMER RESEARCH, 2020, 27 (07)
[5] Design, characterization and preliminary in vitro evaluation of a mucoadhesive polymer based on modified pectin and acrylic monomers with potential use as a pharmaceutical excipient
Villanova, J. C. O.
Ayres, E.
Orefice, R. L.
CARBOHYDRATE POLYMERS, 2015, 121 : 372 - 381
[6] Block copolymers of acrylic acid and butyl acrylate prepared by reversible addition-fragmentation chain transfer polymerization: Synthesis, characterization, and use in emulsion polymerization
Gaillard, N
Guyot, A
Claverie, J
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2003, 41 (05) : 684 - 698
[7] Synthesis and characterization of a new super absorbent polymer (SAP) via the use of low-grade kaolin through inverse suspension polymerization
Lai, Junying
Bi, Yutian
Zhou, Yifan
Qian, Kuangliang
Qian, Xiaoqian
Zeng, Xianhua
Zhu, Qiaoyong
Yu, Feiyu
Ruan, Shaoqin
CONSTRUCTION AND BUILDING MATERIALS, 2023, 363

← 1 →