Genetic factors associated with the development of inflammatory bowel disease

被引：25
|
作者：
Yamamoto-Furusho, Jesus K. [1 ]
机构：
[1] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Gastroenterol, Inflammatory Bowel Dis Clin, Mexico City, DF, Mexico
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2007年 / 13卷 / 42期
关键词：
genetic; susceptibility; inflammatory bowel disease; ulcerative colitis; Crohn's disease;
D O I：
10.3748/wjg.v13.i42.5594
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Crohn's disease (CD) and ulcerative colitis (UC) are complex polygenic disorders, characterized by several genes together with environmental factors contributing to the development of inflammatory bowel disease (IBD). Recent advances in research on genetic susceptibility have allowed the identification of diverse genes at different levels: (1) Innate immunity; (2) Antigen presentation molecules; (3) Epithelial integrity; (4) Drug transporter; (5) Cell adhesion. The application of genetic testing into clinical practice is close and all genetic markers may have several clinical implications: prediction of disease phenotype, molecular classification, prevention of complications, and prognosis. (c) 2007 WJG. All rights reserved.
引用
收藏
页码：5594 / 5597
页数：4
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