Target selection issues in drug discovery and development

被引：1
|
作者：
Sausville, EA [1 ]
机构：
[1] NCI, Dev Therapeut Program, Bethesda, MD 20892 USA
来源：
JOURNAL OF CHEMOTHERAPY | 2004年 / 16卷
关键词：
oncogene; drug target; cancer treatment;
D O I：
10.1179/joc.2004.16.Supplement-1.16
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Targets for cancer treatments have been proposed which address oncogenes mutated in tumors (pathogenic targets). Yet additional opportunities may come from molecules expressed in the tissue of origin (ontogenic); allow drug handling (pharmacological) or address the tumor microenvironment. The key is to define an assay that defines a therapeutic index which can be achieved in modulated target function.
引用
收藏
页码：16 / 18
页数：3
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