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Polymorphisms in the μ-opioid receptor gene (OPRM1) and the implications for alcohol dependence in humans
被引:23
|作者:
van der Zwaluw, Carmen S.
van den Wildenberg, Esther
Wiers, Reinout W.
Franke, Barbara
Buitelaar, Jan
Sebolte, Ron H. J.
Engels, Rutger C. M. E.
机构:
[1] Radboud Univ Nijmegen, Inst Behav Sci, NL-6500 HE Nijmegen, Netherlands
[2] Maastricht Univ, Maastricht, Netherlands
[3] Radboud Univ Nijmegen, Dept Human Genet, Nijmegen Med Ctr, Nijmegen, Netherlands
[4] Radboud Univ Nijmegen, Dept Psychiat, Nijmegen Med Ctr, Nijmegen, Netherlands
[5] IVO Addiction, Res Inst, Rotterdam, Netherlands
关键词:
alcohol;
dependence;
alcoholism;
p-opioid receptor gene;
OPRM1;
polymorphism;
review;
D O I:
10.2217/14622416.8.10.1427
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Twin and adoption studies have shown that alcohol dependence contains a substantial genetic component. In attempts to identify the genetic factors involved, association studies have linked the opioid system to alcohol dependence, with a main focus on the OPRM1 gene encoding the mu-opioid receptor. Our aim was to conduct a systematic review of the literature on the associations between polymorphisms in OPRM1 and alcohol dependence. We addressed findings of 12 studies that met our inclusion criteria. All studies employed a case-control design and included alcohol dependence as a dependent outcome measure. Our review showed that clinical studies do not unequivocally support an association between polymorphisms in OPRM1 and alcohol dependence. Factors that complicate genetic research on alcohol dependence, such as gene-environment interaction, and genetic and clinical heterogeneity, are discussed.
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页码:1427 / 1436
页数:10
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