Features of Mild-to-Moderate COVID-19 Patients With Dysphonia

被引：60

作者：

Lechien, Jerome R. ^{[1
,4
]}

Chiesa-Estomba, Carlos M. ^{[1
,5
]}

Cabaraux, Pierre ^{[1
,6
]}

Mat, Quentin ^{[1
,7
]}

Huet, Kathy ^{[1
,8
]}

Harmegnies, Bernard ^{[1
,8
]}

Horoi, Mihaela ^{[1
,4
]}

Le Bon, Serge Daniel ^{[1
,4
]}

Rodriguez, Alexandra ^{[1
,4
]}

Dequanter, Didier ^{[1
,4
]}

Hans, Stephane ^{[1
,3
]}

Crevier-Buchman, Lise ^{[1
,3
]}

Hochet, Baptiste ^{[1
,3
]}

Distinguin, Lea ^{[1
,3
]}

Chekkoury-Idrissi, Younes ^{[1
,3
]}

Circiu, Marta ^{[1
,3
]}

El Afia, Fahd ^{[1
,3
]}

Barillari, Maria Rosaria ^{[1
,9
]}

Cammaroto, Giovanni ^{[1
,10
]}

Fakhry, Nicolas ^{[1
,11
]}

Michel, Justin ^{[1
,11
]}

Radulesco, Thomas ^{[1
,11
]}

Martiny, Delphine ^{[12
,27
]}

Lavigne, Philippe ^{[1
,13
]}

Jouffe, Lionel ^{[1
,14
]}

Descamps, Geraldine ^{[1
,2
]}

Journe, Fabrice ^{[1
,2
]}

Trecca, Eleonora M. C. ^{[1
,15
]}

Hsieh, Julien ^{[1
,16
]}

Delgado, Irene Lopez ^{[1
,17
]}

Calvo-Henriquez, Christian ^{[1
,18
]}

Vergez, Sebastien ^{[1
,19
]}

Khalife, Mohamad ^{[1
,20
]}

Molteni, Gabriele ^{[1
,21
]}

Mannelli, Giuditta ^{[1
,22
]}

Cantarella, Giovanna ^{[23
,24
]}

Tucciarone, Manuel ^{[1
,25
]}

Souchay, Christel ^{[26
]}

Leich, Pierre ^{[26
]}

Ayad, Tareck ^{[1
,13
]}

Saussez, Sven ^{[2
,3
,20
]}

机构：

[1] COVID 19 Task Force Young Otolaryngologists Int F, Paris, France

[2] Univ Mons UMons, Fac Med, UMONS Res Inst Hlth Sci & Technol, Dept Human Anat & Expt Oncol, Mons, Belgium

[3] Paris Saclay Univ, Univ Versailles St Quentin En Yvelines, Dept Otolaryngol Head & Neck Surg, Foch Hosp,Sch Med,UFR Simone Veil, Paris, France

[4] Univ Libre Bruxelles, Sch Med, Dept Otorhinolaryngol & Head & Neck Surg, CHU Bruxelles,CHU St Pierre, Brussels, Belgium

[5] Hosp Univ Donostia, Dept Otorhinolaryngol Head & Neck Surg, San Sebastian, Spain

[6] CHU Charleroi, Dept Neurol, Charleroi, Belgium

[7] CHU Charleroi, Dept Otolaryngol Head & Neck Surg, Charleroi, Belgium

[8] Univ Mons, Fac Psychol, Dept Language Sci, Mons, Belgium

[9] Univ L Vanvitelli, Dept Mental & Phys Hlth & Prevent Med, Naples, Italy

[10] Morgagni Pierantoni Hosp, Dept Otolaryngol Head & Neck Surg, Forli, Italy

[11] Aix Marseille Univ, La Conception Univ Hosp, AP HM, Dept Otorhinolaryngol Head & Neck Surg, Marseille, France

[12] Univ Lab Brussel LHUB ULB, Lab Hosp Univ Bruxelles, Dept Microbiol, Brussels, Belgium

[13] Ctr Hosp Univ Montreal, Div Otolaryngol Head & Neck Surg, Montreal, PQ, Canada

[14] Bayesia, Change, France

[15] Univ Hosp Foggia, Dept Otolaryngol Head & Neck Surg, Foggia, Italy

[16] Geneva Univ Hosp HUG, Dept Otorhinolaryngol Head & Neck Surg, Rhinol Olfactol Unit, Geneva, Switzerland

[17] Hosp Quironsalud Valencia, Dept Otorhinolaryngol Head & Neck Surg, Valencia, Spain

[18] Hosp Complex Santiago de Compostela, Dept Otolaryngol, Santiago De Compostela, Spain

[19] CHU Rangueil Larrey, Inst Univ Canc Toulouse, Dept Otorhinolaryngol Head & Neck Surg, Toulouse, France

[20] EpiCURA Hosp, Dept Otorhinolaryngol Head & Neck Surg, Baudour, Belgium

[21] Univ Hosp Verona, Div Otolaryngol Head & Neck Surg, Verona, Italy

[22] Univ Florence, Dept Expt & Clin Med, Head & Neck Oncol & Robot Surg, Florence, Italy

[23] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Otolaryngol, Milan, Italy

[24] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[25] Hosp Univ Jerez, Dept Otolaryngol Head & Neck Surg, Jerez de la Frontera, Spain

[26] CHU Ambroise Pare, Dept Otolaryngol Head & Neck Surg, Mons, Belgium

[27] Univ Mons UMONS, Fac Med & Pharm, Mons, Belgium

来源：

JOURNAL OF VOICE | 2022年 / 36卷 / 02期

关键词：

Dysphonia; Covid-19; Coronavirus; Voice; Symptoms; Clinical; Findings; ENT; CORONAVIRUS;

D O I：

10.1016/j.jvoice.2020.05.012

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Introduction. To explore the prevalence of dysphonia in European patients with mild-to-moderate COVID-19 and the clinical features of dysphonic patients. Methods. The clinical and epidemiological data of 702 patients with mild-to-moderate COVID-19 were collected from 19 European Hospitals. The following data were extracted: age, sex, ethnicity, tobacco consumption, comorbidities, general, and otolaryngological symptoms. Dysphonia and otolaryngological symptoms were self-assessed through a 4-point scale. The prevalence of dysphonia, as part of the COVID-19 symptoms, was assessed. The outcomes were compared between dysphonic and nondysphonic patients. The association between dysphonia severity and outcomes was studied through Bayesian analysis. Results. A total of 188 patients were dysphonic, accounting for 26.8% of cases. Females developed more frequently dysphonia than males (P = 0.022). The proportion of smokers was significantly higher in the dysphonic group (P = 0.042). The prevalence of the following symptoms was higher in dysphonic patients compared with nondysphonic patients: cough, chest pain, sticky sputum, arthralgia, diarrhea, headache, fatigue, nausea, and vomiting. The severity of dyspnea, dysphagia, ear pain, face pain, throat pain, and nasal obstruction was higher in dysphonic group compared with nondysphonic group. There were significant associations between the severity of dysphonia, dysphagia, and cough. Conclusion. Dysphonia may be encountered in a quarter of patients with mild-to-moderate COVID-19 and should be considered as a symptom list of the infection. Dysphonic COVID-19 patients are more symptomatic than nondysphonic individuals. Future studies are needed to investigate the relevance of dysphonia in the COVID-19 clinical presentation.

引用

页码：249 / 255

页数：7

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