The human Y chromosome, in the light of evolution

被引：152
|
作者：
Lahn, BT
Pearson, NM
Jegalian, K
机构：
[1] Univ Chicago, Howard Hughes Med Inst, Dept Human Genet, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA
[3] NHGRI, NIH, Bethesda, MD 20892 USA
来源：
NATURE REVIEWS GENETICS | 2001年 / 2卷 / 03期
关键词：
D O I：
10.1038/35056058
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Most eukaryotic chromosomes, akin to messy toolboxes, store jumbles of genes with diverse biological uses. The linkage of a gene to a particular chromosome therefore rarely hints strongly at that gene's function. One striking exception to this pattern of gene distribution is the human Y chromosome. far from being random and diverse, known human Y-chromosome genes show just a few distinct expression profiles. Their relative functional conformity reflects evolutionary factors inherent to sex-specific chromosomes.
引用
收藏
页码：207 / 216
页数：10
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