Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune checkpoint inhibitor-related adverse events

被引：409

作者：

Brahmer, Julie R. ^{[1
]}

Abu-Sbeih, Hamzah ^{[2
]}

Ascierto, Paolo Antonio ^{[3
]}

Brufsky, Jill ^{[4
]}

Cappelli, Laura C. ^{[5
]}

Cortazar, Frank B. ^{[6
,7
]}

Gerber, David E. ^{[8
]}

Hamad, Lamya ^{[9
]}

Hansen, Eric ^{[10
]}

Johnson, Douglas B. ^{[11
]}

Lacouture, Mario E. ^{[12
]}

Masters, Gregory A. ^{[13
]}

Naidoo, Jarushka ^{[1
,14
]}

Nanni, Michele ^{[10
]}

Perales, Miguel-Angel ^{[12
]}

Puzanov, Igor ^{[10
]}

Santomasso, Bianca D. ^{[15
]}

Shanbhag, Satish P. ^{[5
,16
]}

Sharma, Rajeev ^{[10
]}

Skondra, Dimitra ^{[17
]}

Sosman, Jeffrey A. ^{[18
]}

Turner, Michelle ^{[1
]}

Ernstoff, Marc S. ^{[19
]}

机构：

[1] Johns Hopkins Sidney Kimmel Canc Ctr, Dept Oncol & Thorac Oncol, Baltimore, MD USA

[2] Univ Missouri, Dept Internal Med, Kansas City, MO 64110 USA

[3] Natl Tumour Inst IRCCS Fdn G Pascale, Unit Melanoma Canc Immunotherapy & Innovat Therap, Naples, Italy

[4] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA

[5] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[6] Massachusetts Gen Hosp, Boston, MA 02114 USA

[7] New York Nephrol Vasculitis & Glomerular Ctr, Albany, NY USA

[8] Univ Texas Southwestern Med Ctr Dallas, Harold C Simmons Comprehens Canc Ctr, Dept Hematol & Oncol, Dallas, TX 75390 USA

[9] Roswell Park Comprehens Canc Ctr, Dept Pharm, Buffalo, NY USA

[10] Roswell Park Comprehens Canc Ctr, Dept Med, Buffalo, NY USA

[11] Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN USA

[12] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

[13] Helen F Graham Canc Ctr, Dept Med, Delaware, OH USA

[14] Royal Coll Surgeons Ireland, Beaumont Hosp Dublin, Dept Oncol, Dublin, Ireland

[15] Mem Sloan Kettering Canc Ctr, Dept Neurol, 1275 York Ave, New York, NY 10021 USA

[16] Canc Specialist North Florida, Fleming Isl, FL USA

[17] Univ Chicago, Med Ctr, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA

[18] Northwestern Univ, Med Ctr, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[19] NCI, Div Canc Treatment & Diag, Rockville, MD 20850 USA

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2021年 / 9卷 / 06期

关键词：

antineoplastic protocols; guidelines as topic; immunotherapy; PROGRAMMED DEATH 1; MOLECULAR-WEIGHT HEPARIN; ORAL MUCOSITIS PAIN; ACUTE KIDNEY INJURY; CELL LUNG-CANCER; DOUBLE-BLIND; METASTATIC MELANOMA; PREEXISTING AUTOIMMUNE; MYCOPHENOLATE-MOFETIL; SINGLE-CENTER;

D O I：

10.1136/jitc-2021-002435

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint inhibitors (ICIs) are the standard of care for the treatment of several cancers. While these immunotherapies have improved patient outcomes in many clinical settings, they bring accompanying risks of toxicity, specifically immune-related adverse events (irAEs). There is a need for clear, effective guidelines for the management of irAEs during ICI treatment, motivating the Society for Immunotherapy of Cancer (SITC) to convene an expert panel to develop a clinical practice guideline. The panel discussed the recognition and management of single and combination ICI irAEs and ultimately developed evidence- and consensus-based recommendations to assist medical professionals in clinical decision-making and to improve outcomes for patients.

引用

页数：33

共 50 条

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