Field studies were established at two locations in Missouri to determine Amaranthus rudius (common waterhemp) control by single or multiple pre-emergence and/or postemergence herbicide strategies in glyphosate-resistant corn and soybean. The corn study assessed five herbicide strategies: pre-emergence alone; mid-postemergence alone; early posternergence followed by mid-postemergence; pre-emergence followed by mid-postemergence without glyphosate; and pre-emergence followed by glyphosate mid-postemergence. The soybean study assessed four herbicide strategies: mid-postemergence alone; early posternergence followed by mid-postemergence; pre-emergence followed by glyphosate mid-postemergence; and pre-emergence followed by mid-postemergence without glyphosate. In corn, pre-emergence herbicides suppressed A. rudius growth and development 7-34 days longer, compared to the untreated control. The strategies with single herbicide applications provided 21-99% control of A. rudius, while the multiple application strategies provided 84-100% control of A. rudius. In soybean, the presence of pre-emergence herbicides suppressed A. rudius emergence and growth for 7-31 days, compared to treatments with no herbicide application. A single herbicide application provided 69-100% control of A. rudius, and the multiple application strategies were more consistent with 77-100% control. Effective season-long management of A. rudius in glyphosate-resistant corn and soybean should include sequential herbicide applications. (c) 2007 Elsevier Ltd. All rights reserved.