The comparative study on therapeutic effects of intravenous alteplase thrombolysis, intravenous urokinase thrombolysis and interventional urokinase thrombolysis for acute ischemic stroke

Objective: To compare the therapeutic effects of intravenous alteplase thrombolysis, intravenous urokinase thrombolysis and interventional urokinase thrombolysis for acute ischemic stroke. Methods: One hundred and twenty patients of acute ischemic stroke who were treated in our hospital from January 2015 to January 2017 were selected and separated into intravenous alteplase thrombolytic treatment group (Group A, n=40), intravenous urokinase thrombolytic treatment group (Group B, n=40) and interventional urokinase thrombolytic treatment group (Group C, n=40), according to the random number table method. The National Institutes of Health Strike Scale (NIHSS) scores, clinical efficacy, adverse reactions, long-term therapeutic effects of the patients in three groups were statistically analyzed. Results: The differences of NIHSS scores before and after treatment among the three groups were not statistically significant (P=0.125 and P=0.230 respectively); the total effective rates of the three groups were 97.5% (39/40), 95% (38/40), 92.5% (37/40) respectively, the differences of which were not significant in statistics (F=2.77, P=0.223>0.05). The adverse reaction rates of the three groups were 7.5% (3/40), 10% (4/40), 12.5% (5/40) respectively and there were no significant differences (F=4.11, P=0.256>0.05); The differences of recanalization rates, good prognosis rates, mortality rates among the three groups had no statistical significance (F=0.32, 0.45, 0.41, P=0.421, 0.467, 0.362>0.05). Conclusion: Intravenous alteplase thrombolysis, intravenous urokinase thrombolysis and interventional urokinase thrombolysis for acute ischemic stroke have equivalent therapeutic effects.