Synthetic Studies Towards Crinine-Type Amaryllidaceae Alkaloids: Synthesis of (±)-Oxocrinine and Formal Synthesis of (±)-Crinine

被引：11

作者：

Yang, Lijuan ^{[2
,3
]}

Wang, Xuequan ^{[1
]}

Pan, Zhiqiang ^{[1
]}

Zhou, Ming ^{[1
]}

Chen, Wen ^{[2
,3
]}

Yang, Xiaodong ^{[1
]}

机构：

[1] Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China

[2] Yunnan Univ Nationalities, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650031, Yunnan, Peoples R China

[3] Minist Educ, Kunming 650031, Yunnan, Peoples R China

来源：

SYNLETT | 2011年 / 02期

基金：

中国国家自然科学基金;

关键词：

Amaryllidaceae alkaloids; crinine; oxocrinine; total synthesis; quaternary carbon; AZA-COPE REARRANGEMENTS; CONCISE TOTAL-SYNTHESIS; DIELS-ALDER REACTION; SCELETIUM ALKALOIDS; ANTIMALARIAL ACTIVITY; LYCORINE;

D O I：

10.1055/s-0030-1259288

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A flexible strategy leading to the synthesis of crinine-type Amaryllidaceae alkaloids, (+/-)-oxocrinine and (+/-)-crinine, has been developed. A notable feature in this synthetic route is the construction of tetrahydro-1H-benzo[c]azepine framework using an intramolecular Heck reaction and the formation of the sterically congested spiro cyclohexenone intermediate with a Robinson annulation.

引用

页码：207 / 210

页数：4

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