Parallel Solution-Phase Synthesis of a 2-Aminothiazole Library Including Fully Automated Work-Up

被引：5

作者：

Buchstaller, Hans-Peter ^{[1
]}

Anlauf, Uwe ^{[1
]}

机构：

[1] Merck KGaA, Merck Serono, MS RTC MedChem DA35, MS DTC MD1B Med Chem Darmstadt 1B1, D-64293 Darmstadt, Germany

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2011年 / 14卷 / 02期

关键词：

Aminothiazole; combinatorial chemistry; solution phase synthesis; automation; INHIBITORS; DISCOVERY; PROGRESS; DISEASE;

D O I：

10.2174/138620711794474024

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A straightforward and effective procedure for the solution phase preparation of a 2-aminothiazole combinatorial library is described. Reaction, work-up and isolation of the title compounds as free bases was accomplished in a fully automated fashion using the Chemspeed ASW 2000 automated synthesizer. The compounds were obtained in good yields and excellent purities without any further purification procedure.

引用

页码：104 / 108

页数：5

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