Activity of liposomal amphotericin B with prolonged circulation in blood versus those of AmBisome and fungizone against intracellular Candida albicans in murine peritoneal macrophages

被引：8

作者：

Van Etten, EWM ^{[1
]}

Van Vianen, W ^{[1
]}

Hak, J ^{[1
]}

Bakker-Woudenberg, IAJM ^{[1
]}

机构：

[1] Erasmus Univ, Dept Med Microbiol & Infect Dis, NL-3000 DR Rotterdam, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 09期

关键词：

D O I：

10.1128/AAC.42.9.2437

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Activity against intracellular Candida albicans was assessed in C. albicans-infected murine peritoneal macrophages exposed to long-circulating pegylated amphotericin B liposomes (PEG-AMB-LIP), AmBisome, or Fungizone. The level of antifungal activity of Fungizone is much higher than that of AmBisome or PEG-AMB-LIP, while PEG-AMB-LIP and AmBisome show equivalent activity levels. Previous exposure of uninfected macrophages to PEG-AMB-LIP or AmBisome is advantageous for intracellular antifungal activity.

引用

页码：2437 / 2439

页数：3

共 9 条

[1] BIODISTRIBUTION OF LIPOSOMAL AMPHOTERICIN-B (AMBISOME) AND AMPHOTERICIN B-DEOXYCHOLATE (FUNGIZONE) IN UNINFECTED IMMUNOCOMPETENT MICE AND LEUKOPENIC MICE INFECTED WITH CANDIDA-ALBICANS
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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (05) : 2369 - 2371
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MEDICAL MYCOLOGY, 1998, 36 (03) : 135 - 141
[4] In vitro activity of nystatin compared with those of liposomal nystatin, amphotericin B, and fluconazole against clinical Candida isolates
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JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1994, 34 (05) : 840 - 841
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JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 55 (05) : 692 - 698

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