Enzymatic synthesis of carboxyglutamic acid containing peptides in organic media

被引：4
|
作者：
Pera, E [1 ]
Torres, JL [1 ]
Clapes, P [1 ]
机构：
[1] CSIC,CID,UNIT PROT CHEM & BIOCHEM,E-08034 BARCELONA,SPAIN
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 20期
关键词：
D O I：
10.1016/0040-4039(96)00635-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Kinetically-controlled papain-catalyzed synthesis of carboxyglutamic acid containing peptides is reported. The stereoselectivity of papain allowed to use the racemic Z-gamma,gamma'-di-tert-butyl-D,L-Gla-OMe intermediate as acyl donor ester to obtain diasteromerically pure peptide derivatives. As examples, several carboxyglutamic acid containing dipeptide derivatives were synthesized enzymatically in high chemical and enantiomeric yields. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：3609 / 3612
页数：4
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