Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides

被引：6
|
作者：
Divya, Kuppi Reddy Gari [1 ]
Sowmya, Donthamsetty V. [1 ]
Durgamma, Suram [1 ]
Tharanath, Vadlamudi [2 ]
Gopal, Divi Venkataramana Sai [2 ]
Kumar, Malaka Venkateshwarulu Jyothi [3 ]
Rao, Chippada Appa [4 ]
Padmaja, Adivireddy [1 ]
Padmavathi, Venkatapuram [1 ]
机构：
[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India
[2] Sri Venkateswara Univ, Dept Virol, Tirupati 517502, Andhra Pradesh, India
[3] Sri Venkateswara Univ, Dept Biotechnol, Tirupati 517502, Andhra Pradesh, India
[4] Sri Venkateswara Univ, Dept Biochem, Tirupati 517502, Andhra Pradesh, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2017年 / 26卷 / 10期
关键词：
Azoles; Pyrimidines; Antioxidant activity; Antiviral activity; CYANOBACTERIUM LYNGBYA-MAJUSCULA; IMIDAZOLE DERIVATIVES; ANTIINFLAMMATORY ACTIVITIES; SUBSTITUTED PYRIMIDINES; SCAVENGING PROPERTIES; CYCLIC HEXAPEPTIDES; ANTICANCER ACTIVITY; DIDMOLAMIDE-A; INHIBITORS; AGENTS;
D O I：
10.1007/s00044-017-1956-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new class of pyrimidinylsulfamoyl azolyl acetamides was prepared from 2-pyrimidinylsulfamoyl acetic acid and 2-aminoazoles. The methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamide (8e) displayed moderate antioxidant activity. The methyl and methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamides (8b, 8e) exhibited antiviral activity on BHK 21 cell lines with IC50 63.5, 44.5 A mu g/mL, respectively. The compound 8e inhibited cytopathic changes induced by Blue Tongue Virus in cell lines.
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页码：2568 / 2582
页数：15
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