The purpose of this study was to evaluate the benefit, if any, of routine monitoring of vital signs on clinical outcomes in hospitalized patients with deep venous thrombosis (DVT). One hundred forty-nine patients with DVT included in this study were categorized into two groups: those that underwent measurement of vital signs every 6 hours or those that had vital sips measured every 8 hours. Vital signs included pulse, blood pressure, respiratory rate, and temperature. Frequency of measurement of vital sips did not alter average length of stay; for patients with every-4-hours measurement, this was 5.16 days and was not statistically significant from patients with every-8-hours measurement, who stayed an average of 4.85 days (p = 0.507). Similarly, more frequent vital sip evaluation did not result in a statistically significant difference in survival, progression of disease, nor did it predict the disposition of the patient. These results suggest that present frequency of measurement of vital sips is not cost or time effective because they do not result in a favorable outcome, length of stay, or disposition. The study further serves to highlight the need for an individualized assessment of vital sip measurement, because this will also lead to a more efficient allocation of hospital resources.