SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 5-AMINO-2-MERCAPTO-1,3,4-THIADIAZOLE DERIVATIVES THIOETERS AND SCHIFF BASES

被引：0

作者：

Rad, Oana ^{[1
]}

Tibor, Rozsa ^{[1
]}

Duma, Mihaela ^{[2
]}

Vlase, Laurian ^{[3
]}

Pirnau, Adrian ^{[4
]}

Tiperciuc, Brindusa ^{[1
]}

Ionut, Ioana ^{[1
]}

Oniga, Ovidiu ^{[1
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmaceut Chem, 41 Victor Babes St, Cluj Napoca 400012, Romania

[2] State Vet Lab Anim Hlth & Food Safety, Cluj Napoca 400572, Romania

[3] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmaceut Technol & Biopharmaceut, Fac Pharm, 41 Victor Babes St, Cluj Napoca 400012, Romania

[4] Natl Inst Res & Dev Isotop & Mol Technol, 1 Donath St, Cluj Napoca, Romania

来源：

STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA | 2016年 / 61卷 / 01期

关键词：

1,3,4-thiadiazole; antibacterial activity; antifungal activity; BIOLOGICAL EVALUATION; HETEROCYCLES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Starting from 5-amino-2-mercapto-1,3,4-thiadiazole, 23 compounds, Schiff bases and S-mercapto-substituted derivatives, were synthesized. Their structural elucidation was based on elemental analysis, mass spectrometry and proton nuclear magnetic resonance spectroscopy (H-1 NMR). The screening of the antimicrobial activity of the title compounds was realized using the diffusimetric method against several strains of Gram-positive and Gram-negative bacteria and one fungal strain (Candida albicans). Some of the molecules showed moderate to good antibacterial activity against Gramnegative (S. typhimurium, E. coli) and better activity against Gram-positive (B. cereus, L. monocytogenes, S. aureus) bacterial strains. All compounds exhibited moderate to very good activity against C. albicans. Qualitative relationships (SAR) were also established between the chemical structures and the antimicrobial activity of these compounds.

引用

页码：17 / 32

页数：16

共 50 条

[1] Synthesis of 2-amino-5-mercapto-1,3,4-thiadiazole derivatives
Li, Wen-You
Song, Yong
Chen, Hong-Bo
Yang, Wen-Long
HETEROCYCLIC COMMUNICATIONS, 2014, 20 (01) : 33 - 36
[2] 1,3,4-thiadiazole derivatives .5. Heteropolynuclear complexes of 2-amino-5-mercapto-1,3,4-thiadiazole
Brezeanu, M
Olar, R
Meghea, A
Stanica, N
Supuran, CT
REVUE ROUMAINE DE CHIMIE, 1996, 41 (1-2) : 103 - 107
[3] QSAR analysis of some 5-amino-2-mercapto-1,3,4-thiadiazole based inhibitors of matrix metalloproteinases and bacterial collagenase
Jamloki, Ashutosh
Karthikeyan, C.
Moorthy, N. S. Hari Narayana
Trivedi, P.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (14) : 3847 - 3854
[4] Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives
Farghaly, Thoraya A.
Abdallah, Magda A.
Aziz, Mohamed R. Abdel
MOLECULES, 2012, 17 (12) : 14625 - 14636
[5] Synthesis of metallic azoderivatives of 2-amino-5-mercapto-1,3,4-thiadiazole
Ortega-Luoni, Pedro
Vera, Leonel
Astudillo, Claudio
Guzman, Miguel
Ortega-Lopez, Pedro
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, 2007, 52 (01): : 1120 - 1122
[6] Electrochemical polymerized 5-amino-2-mercapto-1,3,4-thiadiazole modified single use sensors for detection of quercetin
Muti, Mihrican
Gencdag, Kubra
Nacak, Fatma Merve
Aslan, Alican
COLLOIDS AND SURFACES B-BIOINTERFACES, 2013, 106 : 181 - 186
[7] Synthesis and Antimicrobial Evaluation of Some 1,3,4-Thiadiazole Derivatives
Shashikant, Pattan R.
Desai, N. S.
Rabara, P. A.
Bukitgar, A. A.
Wakale, V. S.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2008, 42 (04) : 314 - 318
[8] Synthesis and antibacterial activity of several nonvel schiff bases bearing acetylferrocenyl and 2-amino-5-substituted-1,3,4-thiadiazole
Liu, Yuting
Chen, Shu
Yin, Dawei
ADVANCES IN CHEMICAL ENGINEERING, PTS 1-3, 2012, 396-398 : 1067 - 1070
[9] Synthesis, spectral and antimicrobial studies of bis(cyclopentadienyl)titanium(IV) derivatives with Schiff bases derived from 2-amino-5-phenyl-1,3,4-thiadiazole
Srivastava, AK
Pandey, OP
Sengupta, SK
BIOINORGANIC CHEMISTRY AND APPLICATIONS, 2005, 3 (3-4) : 289 - 297
[10] Protease inhibitors: Synthesis of matrix metalloproteinase and bacterial collagenase inhibitors incorporating 5-amino-2-mercapto-1,3,4-thiadiazole zinc binding functions
Scozzafava, A
Supuran, CT
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (19) : 2667 - 2672

← 1 2 3 4 5 →