An evolutionally primitive farnesoid X receptor (FXR) demonstrates greater ligand promiscuity than its mammalian ortholog

被引:0
|
作者
Cai, SY
Xiong, LS
Ballatori, N
Boyer, J
机构
[1] Yale Univ, Sch Med, New Haven, CT USA
[2] Univ Rochester, Sch Med, Rochester, NY USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:504A / 504A
页数:1
相关论文
共 11 条
  • [1] Natural Products as Farnesoid X Receptor (FXR) Agonists: Their Interactions with FXR Ligand Binding Region
    Lin, Hsiang-Ru
    MINI-REVIEWS IN ORGANIC CHEMISTRY, 2016, 13 (02) : 97 - 108
  • [2] The farnesoid X receptor (FXR) controls gene expression in a ligand- and promoter-selective fashion
    Lo, JL
    Zhao, A
    Yu, JH
    Huang, L
    Wright, SD
    Cui, JS
    CIRCULATION, 2002, 106 (19) : 72 - 72
  • [3] Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
    Wang, Na
    Zou, Qingan
    Xu, Jinxin
    Zhang, Jiancun
    Liu, Jinsong
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (47) : 18180 - 18191
  • [4] The p300 Acetylase Is Critical for Ligand-activated Farnesoid X Receptor (FXR) Induction of SHP
    Fang, Sungsoon
    Tsang, Stephanie
    Jones, Ryan
    Ponugoti, Bhaskar
    Yoon, Hyeryoung
    Wu, Shwu-Yuan
    Chiang, Cheng-Ming
    Willson, Timothy M.
    Kemper, Jongsook Kim
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (50) : 35086 - 35095
  • [5] Activated-farnesoid X receptor (FXR) expressed in human sperm alters its fertilising ability
    Malivindi, R.
    Santoro, M.
    De Rose, D.
    Panza, S.
    Gervasi, S.
    Rago, V.
    Aquila, S.
    REPRODUCTION, 2018, 156 (03) : 249 - 259
  • [6] Ligand-binding domain of farnesoid X receptor (FXR) had the highest sensitivity and activity among FXR variants in a fluorescence-based assay
    Cho, KH
    Park, JY
    Han, JI
    Jeong, TS
    LIPIDS, 2003, 38 (11) : 1149 - 1156
  • [7] The farnesoid X receptor FXRα/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution
    Cai, Shi-Ying
    Xiong, Liangshi
    Wray, Charles G.
    Ballatori, Nazzareno
    Boyer, James L.
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 293 (03) : R1400 - R1409
  • [8] 3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism
    Stefela, Alzbeta
    Kaspar, Miroslav
    Drastik, Martin
    Holas, Ondrej
    Hroch, Milos
    Smutny, Tomas
    Skoda, Josef
    Hutnikova, Miriama
    Pandey, Amit V.
    Micuda, Stanislav
    Kudova, Eva
    Pavek, Petr
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2020, 202
  • [9] Design and identification of a new farnesoid X receptor (FXR) partial agonist by computational structure-activity relationship analysis: Ligand-induced H8 helix fluctuation in the ligand-binding domain of FXR may lead to partial agonism
    Gohda, Keigo
    Iguchi, Yusuke
    Masuda, Arisa
    Fujimori, Ko
    Yamashita, Yukiko
    Teno, Naoki
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 41
  • [10] INVITRO PROLIFERATION OF PRIMITIVE HEMATOPOIETIC STEM-CELLS SUPPORTED BY STROMAL CELLS - EVIDENCE FOR THE PRESENCE OF A MECHANISM(S) OTHER THAN THAT INVOLVING C-KIT RECEPTOR AND ITS LIGAND
    KODAMA, H
    NOSE, M
    YAMAGUCHI, Y
    TSUNODA, J
    SUDA, T
    NISHIKAWA, S
    NISHIKAWA, S
    JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (02): : 351 - 361