The role of prostate cancer antigen 3 (PCA3) in prostate cancer detection

被引：20
|
作者：
Ploussard, Guillaume [1 ]
de la Taille, Alexandre [2 ,3 ]
机构：
[1] St Jean Languedoc La Croix Sud Hosp, Dept Urol, Creteil, France
[2] CHU Henri Mondor, APHP, Inst Univ Canc Toulouse Oncopole, Creteil, France
[3] Univ Paris 12, INSERM, U955, Equipe 7, Creteil, France
来源：
EXPERT REVIEW OF ANTICANCER THERAPY | 2018年 / 18卷 / 10期
关键词：
Prostate cancer; detection; PCA3; biomarker; low risk; MOLECULAR URINE TEST; MULTIPARAMETRIC MAGNETIC-RESONANCE; PREVIOUS NEGATIVE BIOPSIES; ACTIVE SURVEILLANCE; REPEAT BIOPSY; TUMOR VOLUME; PRESCREENED MEN; HEALTH INDEX; PERFORMANCE; GENE;
D O I：
10.1080/14737140.2018.1502086
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Introduction: The prostate cancer antigen 3 (PCA3) score has been the first urine assay to obtain the Food and Drug Administration approval for guiding decisions regarding additional biopsies. Different aspects of this urinary assay (diagnostic performance, prognostic value, cost/benefit balance, integration with other molecular and imaging modalities) have now been well evaluated.Areas covered: This expert review will summarize current achievements and future perspectives provided by this urine biomarker.Expert commentary: The clinical benefit of the PCA3 score, in addition to the other established factors has been demonstrated before regarding biopsy decision making in men with persistent risk of prostate cancer. Its potential prognostic value also suggests its usefulness in selecting low risk patients for active surveillance protocols, however future daily-practice changing studies are needed. Economics assessment and additional value compared with other biomolecular and imaging modalities are still under investigation.
引用
收藏
页码：1013 / 1020
页数：8
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