Heat shock protein-based novel immunotherapies

被引：26
|
作者：
Srivastava, PK [1 ]
机构：
[1] Univ Connecticut, Sch Med, Ctr Immunotherapy Canc & Infect Dis MC1601, Farmington, CT 06030 USA
来源：
DRUG NEWS & PERSPECTIVES | 2000年 / 13卷 / 09期
关键词：
D O I：
10.1358/dnp.2000.13.9.858479
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The ability of heat shock proteins to chaperone peptides, including antigenic peptides; to interact with antigen-presenting cells through a receptor; to stimulate antigen-presenting cells to secrete inflammatory cytokines; and to mediate maturation of dendritic cells makes them a unique starting point for generation of immune responses. These properties also permit the utilization of heat shock proteins for development of a new generation of prophylactic and therapeutic vaccines against cancers and infectious diseases. (C) 2000 Prous Science. All rights reserved.
引用
收藏
页码：517 / 522
页数：6
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