Effects of a nitric oxide synthase inhibitor on hypophagia induced by the peripheral 5-HT receptor agonists, α-methyl-5-hydroxytryptamine and 5-carboxamidotryptamine in rats

被引：0
|
作者：
Sugimoto, Y [1 ]
Noma, T [1 ]
Yoshikawa, T [1 ]
Yamada, J [1 ]
机构：
[1] Kobe Pharmaceut Univ, Dept Pharmacol, Higashinada Ku, Kobe, Hyogo 6588558, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2000年 / 23卷 / 12期
关键词：
5-HT; NO; food intake; 5-HT2A receptor; 5-HT7; receptor; alpha-methyl-5-HT; 5-CT;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the effects of the nitric oxide (NO) synthase inhibitor, N-G-nitro-L-arginine methyl ester (L-NAME) on hypophagia in rats elicited by alpha -methyl-5-hydroxytryptamine (alpha -methyl-5-HT) and 5-carboxamidotryptamine (5-CT) which are suggested to be mediated by the peripheral 5-HT2A and 5-HT7 receptor, respectively. Both alpha -methyl-5-HT and 5-CT apparently inhibited food intake in food-deprived rats. L-NAME significantly enhanced alpha -methyl-5-HT-elicited hypophagia, while it inhibited 5-CT-elicited hypophagia. These results suggest that NO is differentially related to alpha -methyl-5-HT and 5-CT-induced hypophagia and that NO may play a role in hypo- and hyperphagia.
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页码：1514 / 1516
页数：3
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