Targeted anticancer drug delivery through anthracycline antibiotic bearing functionalized quantum dots

被引：17
|
作者：
Bajwa, Neha [1 ]
Mehra, Neelesh Kumar [1 ,2 ]
Jain, Keerti [1 ]
Jain, Narendra Kumar [1 ]
机构：
[1] ISF Coll Pharm, Pharmaceut Nanotechnol Res Lab, Moga, Punjab, India
[2] Texas A&M Hlth Sci Ctr, Irma Lerma Rangel Coll Pharm, Dept Pharmaceut Sci, Kingsville, TX 78363 USA
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 07期
关键词：
Chitosan; doxorubicin HCL; folic acid; imaging; quantum dots; targeting; DOXORUBICIN DELIVERY; CARBON NANOTUBES; THERAPY;
D O I：
10.3109/21691401.2015.1102740
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We herein first report a method for the synthesis of chitosan (CHI)-folate conjugated colloidal ZnO-Mn+2 quantum dots (QDs) bearing doxorubicin through chemical method (DOX/FA-CHI-QDs) for cancer therapy as well imaging purpose. The entrapment efficiency was determined to be 99.98 +/- 0.012% (DOX/FA-CHI-QDs) and 92.0 +/- 2.62% (DOX-QDs). The developed DOX/FA-CHI-QDs formulations depict the sustained release pattern at the lysosomal pH (pH 5.0). The DOX/FA-CHI-QDs showed enhanced cytotoxicity, cellular uptake and were most preferentially taken up by the cancerous cells via receptor-mediated endocytosis (RME) mechanism. Hence, the QD-based formulation is capable of targeting drug delivery and imaging the delivery process.
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页码：1774 / 1782
页数：9
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