Organocatalyzed Kabbe condensation reaction for mild and expeditious synthesis of 2,2-dialkyl and 2-spiro-4-chromanones

被引：7

作者：

Kapuriya, Naval P. ^{[1
]}

Bhalodia, Jasmin J. ^{[1
]}

Ambasana, Mrunal A. ^{[1
]}

Patel, Rashmi B. ^{[1
]}

Bapodra, Atul H. ^{[1
]}

机构：

[1] Bhakta Kavi Narsinh Mehta Univ, Dept Chem & Forens Sci, Bilkha Rd, Jungadh 362263, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 09期

关键词：

ASYMMETRIC ALDOL REACTIONS; DISCOVERY; ALDEHYDES; RING;

D O I：

10.1002/jhet.4054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An expeditious Kabbe condensation reaction for the synthesis of 2,2-dialkyl and 2-spiro-chroman-4(1H)-ones has been developed using pyrrolidine-butanoic acid in DMSO as bifunctional organocatalyst. Unlike existing methods, this reaction proceeds at room temperature with high yields, rendering it an attractive method to synthesize a vast variety of privileged 4-chromones.

引用

页码：3369 / 3374

页数：6

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