Membrane channel activity and translocation of tetanus and botulinum neurotoxins

被引：21
|
作者：
Lebeda, FJ
Singh, BR [1 ]
机构：
[1] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Toxinol Div, Frederick, MD 21702 USA
[2] Univ Massachusetts, Dept Chem, N Dartmouth, MA 02747 USA
来源：
JOURNAL OF TOXICOLOGY-TOXIN REVIEWS | 1999年 / 18卷 / 01期
基金：
美国国家卫生研究院;
关键词：
protein-membrane interactions; protein structure; oligomerization; diphtheria toxin; anthrax protective antigen; Staphylococcus aureus alpha-hemolysin;
D O I：
10.3109/15569549909036017
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
This review centers on the structure and function of ionic channels formed by clostridial neurotoxins. Questions regarding their structure, the pathways for their formation, and their role in translocating the toxic moiety across an endocytotic membrane are discussed.
引用
收藏
页码：45 / 76
页数：32
相关论文
共 50 条
  • [1] Membrane translocation of tetanus and botulinum neurotoxins
    Pirazzini, M.
    Rossetto, O.
    Bordin, F.
    Shone, C. C.
    Binz, T.
    Montecucco, C.
    TOXICON, 2013, 75 : 209 - 209
  • [2] On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments
    Pirazzini, Marco
    Tehran, Domenico Azarnia
    Leka, Oneda
    Zanetti, Giulia
    Rossetto, Ornella
    Montecucco, Cesare
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2016, 1858 (03): : 467 - 474
  • [3] Botulinum and Tetanus Neurotoxins
    Dong, Min
    Masuyer, Geoffrey
    Stenmark, Pal
    ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88, 2019, 88 : 811 - 837
  • [4] Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons
    Pirazzini, Marco
    Rossetto, Ornella
    Bertasio, Cristina
    Bordin, Fulvio
    Shone, Clifford C.
    Binz, Thomas
    Montecucco, Cesare
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 430 (01) : 38 - 42
  • [5] Comparative Membrane Channel Size and Activity of Botulinum Neurotoxins A and E
    Sweta Parikh
    Bal Ram Singh
    The Protein Journal, 2007, 26 : 19 - 28
  • [6] Comparative membrane channel size and activity of botulinum neurotoxins A and E
    Parikh, Sweta
    Singh, BalRam
    PROTEIN JOURNAL, 2007, 26 (01): : 19 - 28
  • [7] In vitro biological activity and toxicity of tetanus and botulinum neurotoxins
    Pellizzari, R
    Rossetto, O
    Washbourne, P
    Tonello, F
    Nicotera, PL
    Montecucco, C
    TOXICOLOGY LETTERS, 1998, 103 : 191 - 197
  • [8] Botulinum and tetanus neurotoxins: Emerging tools for the study of membrane fusion
    Jahn, R
    Hanson, PI
    Otto, H
    AhnertHilger, G
    COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1995, 60 : 329 - 335
  • [9] MEMBRANE INTERACTIONS OF TETANUS AND BOTULINUM NEUROTOXINS - A PHOTOLABELING STUDY WITH PHOTOACTIVATABLE PHOSPHOLIPIDS
    SCHIAVO, G
    BOQUET, P
    DASGUPTA, BR
    MONTECUCCO, C
    JOURNAL DE PHYSIOLOGIE, 1990, 84 (02): : 180 - 187
  • [10] Structure and function of tetanus and botulinum neurotoxins
    Montecucco, C
    Schiavo, G
    QUARTERLY REVIEWS OF BIOPHYSICS, 1995, 28 (04) : 423 - 472
12345