Dynamic contrast-enhanced MRI and Doppler sonography in patients with squamous cell carcinoma of head and neck treated with induction chemotherapy

被引:1
|
作者
Chawla, Sanjeev [1 ]
Loevner, Laurie [1 ]
Mohan, Suyash [1 ]
Lin, Alexander [2 ]
Sehgal, Chandra M. [1 ]
Poptani, Harish [3 ]
机构
[1] Univ Penn, Dept Radiol, Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Radiat Oncol, Perelman Sch Med, Philadelphia, PA 19104 USA
[3] Univ Liverpool, Dept Mol & Clin Canc Med, Liverpool, Merseyside, England
基金
美国国家卫生研究院;
关键词
Doppler sonography; dynamic contrast enhanced-MRI; head and neck squamous cell carcinoma; induction chemotherapy; perfusion parameters; CERVICAL LYMPH-NODES; GRAY-SCALE; CANCER; PARAMETERS; DIAGNOSIS; CHEMORADIOTHERAPY; LYMPHADENOPATHY; VASCULARITY; PERFUSION; DISEASE;
D O I
10.1002/jcu.23361
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
In view of the inherent limitations associated with performing dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in clinical settings, current study was designed to provide a proof of principle that Doppler sonography and DCE-MRI derived perfusion parameters yield similar hemodynamic information from metastatic lymph nodes in squamous cell carcinomas of head and neck (HNSCCs). Strong positive correlations between volume fraction of plasma space in tissues (V-p) and blood volume (r = 0.72, p = 0.02) and between V-p and %area perfused (r = 0.65, p = 0.04) were observed. Additionally, a moderate positive correlation trending towards significance was obtained between volume transfer constant (K-trans) and %area perfused (r = 0.49, p = 0.09).
引用
收藏
页码:1353 / 1359
页数:7
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