Validation of a screening questionnaire for hip and knee osteoarthritis in old people

Background: To develop a sensitive and specific screening tool for knee and hip osteoarthritis in the general population of elderly people. Methods: The Knee and Hip OsteoArthritis Screening Questionnaire (KHOA- SQ) was developed based on previous studies and observed data and sent to 11,002 people aged 60 to 90 years, stratified by age and gender, who were selected by random sampling. Algorithms of the KHOA- SQ were created. Respondents positive for knee or hip OA on the KHOA- SQ were invited to be evaluated by an orthopedic surgeon. A sample of 300 individuals negative for knee or hip OA on the KHOA- SQ were also invited for evaluation. Sensitivity and specificity were determined for the KHOA- SQ, as well as for KHOA- SQ questions. Classification and Regression Tree analysis was used to find alternative screening algorithms from the questionnaire. Results: Of 11,002 individuals contacted, 7,577 completed the KHOA- SQ. Of 1,115 positive for knee OA, on the KHOA- SQ, 710 ( 63.6%) were diagnosed with it. For hip OA, 339 of the 772 who screened positive ( 43.9%) were diagnosed it. Sensitivity for the hip algorithm was 87.4% and specificity 59.8%; for the knee, sensitivity was 94.5% and specificity 43.8%. Two alternative algorithms provided lower specificity. Conclusion: The KHOA- SQ offers high sensitivity and moderate specificity. Although this tool correctly identifies individuals with knee or hip OA, the high false positive rate could pose problems. Based on our questions, no better algorithm was found.