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A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica
被引:188
|作者:
Schlossbauer, Axel
[1
,2
]
Warncke, Simon
[3
]
Gramlich, Philipp M. E.
[1
,2
]
Kecht, Johann
[1
,2
]
Manetto, Antonio
[3
]
Carell, Thomas
[1
,2
]
Bein, Thomas
[1
,2
]
机构:
[1] Univ Munich LMU, Dept Chem, D-81377 Munich, Germany
[2] Univ Munich LMU, Ctr NanoSci CeNS, D-81377 Munich, Germany
[3] Baseclick GmbH, D-82327 Tutzing, Germany
关键词:
click chemistry;
colloids;
DNA;
host-guest systems;
nanotechnology;
RESPONSIVE CONTROLLED-RELEASE;
DRUG-DELIVERY;
CLICK CHEMISTRY;
NANOPARTICLES;
FUNCTIONALIZATION;
NANOSPHERE;
SUPPORTS;
SYSTEM;
D O I:
10.1002/anie.201000827
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
(Figure Presented) Letting off steam: A temperature-controlled valve system permits the targeted release of guest fluorescein molecules from the pores of colloidal mesoporous silica particles. The pore-opening temperature is dependent on the length of double-stranded DNA linkers. Avidin proteins that are joined to the DNA by a biotin modification act as the molecular valve at the exits to the pores. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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页码:4734 / 4737
页数:4
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