Synthesis and characterization of alginate and sterculia gum based hydrogel for brain drug delivery applications

被引：31
|
作者：
Singh, Baljit [1 ]
Kumar, Ajay [1 ]
Rohit [1 ]
机构：
[1] Himachal Pradesh Univ, Dept Chem, Shimla 171005, Himachal Prades, India
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2020年 / 148卷
关键词：
Graft co-polymerization; Drug delivery; Hydrogels; Alginate; SPINAL-CORD; NERVE REGENERATION; PHYSICOCHEMICAL CHARACTERIZATION; WOUND DRESSINGS; ACRYLIC-ACID; CDP-CHOLINE; CHITOSAN; RELEASE; MEMBRANES; POLYMER;
D O I：
10.1016/j.ijbiomac.2020.01.147
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present work deals with the design of the alginate, sterculia gum polysaccharide and PVP based hydrogel for brain drug delivery applications. The release dynamics of citicoline drug, a nerve regenerating agent, was evaluated. The polymers were investigated by Cryo-SEMs, AFM, FTIR, XRD, C-13 NMR, and swelling studies. The drug release occurred slowly without burst effect and followed mechanism that was approaching the Fickian diffusion mechanism and first order kinetic model. The polymer matrix showed drug loading 40.0 +/- 0.8%, thrombose percentage 68.70 +/- 8.95%, hemolytic index value 3.66 +/- 1.65%, detachment force from the intestinal mucosa = 0.124 +/- 0.04 N, and tensile strength 7.67 +/- 0.40 N/mm(2). These films were found biocompatible, antioxidant and mucoadhesive and could be explored for brain drug delivery. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页码：248 / 257
页数：10
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