No rest for REST: REST/NRSF regulation of neurogenesis

被引：98

作者：

Lunyak, VV ^{[1
]}

Rosenfeld, MG ^{[1
]}

机构：

[1] Univ Calif San Diego, Howard Hughes Med Inst, Dept Med, La Jolla, CA 92093 USA

来源：

CELL | 2005年 / 121卷 / 04期

关键词：

D O I：

10.1016/j.cell.2005.05.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epigenetic strategies control the orderly acquisition and maintenance of neuronal traits. A complex network of transcriptional repressors and corepressors mediates gene specificity for these strategies. In this issue of Cell, a study by Ballas and coworkers (Ballas et al., 2005) provides insight into the early lineage commitment events during neurogenesis. This study demonstrates that regulation of the REST/NRSF transcriptional repressor plays a fundamental role in the progression of pluripotent cells to lineage-restricted neural progenitors.

引用

页码：499 / 501

页数：3

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