Procalcitonin as a prognostic marker in patients with acute myocardial infarction

被引：48

作者：

Kelly, Dominic ^{[1
]}

Khan, Sohail Q. ^{[1
]}

Dhillon, Onkar ^{[1
]}

Quinn, Paulene ^{[1
]}

Struck, Joachim ^{[2
]}

Squire, Iain B. ^{[1
]}

Davies, Joan E. ^{[1
]}

Ng, Leong L. ^{[1
]}

机构：

[1] Univ Leicester, Leicester Royal Infirm, Dept Cardiovasc Sci, Leicester LE2 7LX, Leics, England

[2] BRAHMS AG, Berlin, Germany

来源：

BIOMARKERS | 2010年 / 15卷 / 04期

关键词：

Myocardial infarction; heart failure; biomarkers; procalcitonin; ACUTE CORONARY SYNDROME; SERUM PROCALCITONIN;

D O I：

10.3109/13547501003675084

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: Procalcitonin is involved in the inflammatory response and is associated with adverse prognosis in certain conditions. Aims: To investigate the association between procalcitonin and major adverse cardiac events (MACE), left ventricular (LV) function and remodelling following acute myocardial infarction (AMI). Methods: Plasma procalcitonin was measured in 977 patients with AMI. Subjects were followed for MACE (median 671 days). A subgroup underwent echocardiography at discharge and follow-up LV function and volume assessment. Results: Procalcitonin was associated with MACE on uni- and multivariable analysis. Kaplan-Meier assessment revealed an adverse outcome in subjects with procalcitonin above the median. Procalcitonin was related to markers of LV dysfunction and remodelling. Conclusion: Procalcitonin is associated with MACE, LV dysfunction and remodelling post-AMI.

引用

页码：325 / 331

页数：7

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