Glufosinate ammonium induces convulsion through N-methyl-D-aspartate receptors in mice

被引：25
|
作者：
Matsumura, N [1 ]
Takeuchi, C [1 ]
Hishikawa, K [1 ]
Fujii, T [1 ]
Nakaki, T [1 ]
机构：
[1] Teikyo Univ, Sch Med, Dept Pharmacol, Itabashi Ku, Tokyo 1738605, Japan
来源：
NEUROSCIENCE LETTERS | 2001年 / 304卷 / 1-2期
关键词：
convulsion; glufosinate ammonium; N-methyl-D-asparate; LY235959; Compound; 40; dizocilpine; NBQX;
D O I：
10.1016/S0304-3940(01)01765-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Glufosinate ammonium, a broad-spectrum herbicide, causes convulsion in rodents and humans. Because of the structural similarities between glufosinate and glutamate, the convulsion induced by glufosinate ammonium may be ascribed to glutamate receptor activation. Three N-methyl-D-asparate (NMDA) receptor antagonists, dizocilpine, LY235959, and Compound 40, and an alpha -amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor antagonist, NBQX, were coadministrated with glufosinate ammonium (80 mg/kg, intraperitoneally) in mice. Statistical analyses showed that the NMDA receptor antagonists markedly inhibited the convulsions, while the AMPA/kainate receptor antagonist had no effect on the convulsion. These results suggest that the convulsion caused by glufosinate ammonium is mediated through NMDA receptors. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：123 / 125
页数：3
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