Gastrointestinal disorders in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: A review for the gastroenterologist

被引:51
|
作者
Beckers, A. B. [1 ]
Keszthelyi, D. [1 ]
Fikree, A. [2 ]
Vork, L. [1 ]
Masclee, A. [1 ]
Farmer, A. D. [2 ,3 ]
Aziz, Q. [2 ]
机构
[1] Maastricht Univ, Med Ctr, Dept Internal Med, Div Gastroenterol Hepatol, Maastricht, Netherlands
[2] Queen Mary Univ London, Wingate Inst Neurogastroenterol, Ctr Digest Dis, Blizard Inst,Barts & London Sch Med & Dent, London, England
[3] Univ Hosp North Midlands, Dept Gastroenterol, Stoke On Trent, Staffs, England
来源
NEUROGASTROENTEROLOGY AND MOTILITY | 2017年 / 29卷 / 08期
关键词
Ehlers-Danlos syndrome; functional dyspepsia; functional GI disorders; joint hypermobility syndrome; IRRITABLE-BOWEL-SYNDROME; PSYCHOLOGICAL DISTRESS; ANXIETY DISORDERS; CONNECTIVE-TISSUE; CELIAC-DISEASE; TENASCIN-X; MANIFESTATIONS; DYSFUNCTION; DYSAUTONOMIA; ASSOCIATION;
D O I
10.1111/nmo.13013
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
BackgroundJoint hypermobility syndrome (JHS)/Ehlers-Danlos syndrome hypermobility type (EDS-HT) is the most common hereditary non-inflammatory disorder of connective tissue, characterized by a wide range of symptoms, mainly joint hyperextensibility and musculoskeletal symptoms. A majority of patients also experiences gastrointestinal (GI) symptoms. Furthermore, JHS/EDS-HT has specifically been shown to be highly prevalent in patients with functional GI disorders, such as functional dyspepsia and irritable bowel syndrome. PurposeThe aim of this review was to examine the nature of GI symptoms and their underlying pathophysiology in JHS/EDS-HT. In addition, we consider the clinical implications of the diagnosis and treatment of JHS/EDS-HT for practicing clinicians in gastroenterology. Observations summarized in this review may furthermore represent the first step toward the identification of a new pathophysiological basis for a substantial subgroup of patients with functional GI disorders.
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页数:10
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