Magnetic immunoassays utilizing magnetic markers and a high-TC SQUID

被引：23
|
作者：
Enpuku, K [1 ]
Inoue, K
Soejima, K
Yoshinaga, K
Kuma, H
Hamasaki, N
机构：
[1] Kyushu Univ, Res Inst Superconductor Sci & Syst, Fukuoka 8128581, Japan
[2] Kyushu Inst Technol, Dept Appl Chem, Kitakyushu, Fukuoka 8048550, Japan
[3] Kyushu Univ, Dept Med Sci, Fukuoka 8128582, Japan
来源：
IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY | 2005年 / 15卷 / 02期
关键词：
high-T-C SQUID; immunoassay; magnetic nanoparticle; remanence;
D O I：
10.1109/TASC.2005.849991
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Magnetic immunoassays utilizing magnetic markers and a high-T-c SQUID have been performed. We first showed a design of the SQUID for the sensitive detection of the magnetic signal from the marker, where the spatial distribution of the signal field was taken into account. Using the design, we can obtain the relationship between the magnetization of the maker and the signal flux detected with the SQUID. This relationship is important for quantitative evaluation of the immunoassay. Next, we detected biological materials called IgE with a remanence measurement method, where a marker made of Fe3O4 particles with diameter of 25 nm was used. We showed that 2 atto-mol of IgE can be detected, which shows high sensitivity of the present method.
引用
收藏
页码：660 / 663
页数：4
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