Postoperative lung injury and oxidative damage in patients undergoing pulmonary resection

被引:54
|
作者
Williams, EA
Quinlan, GJ
Goldstraw, P
Gothard, JWW
Evans, TW
机构
[1] Royal Brompton Hosp, Intens Care Unit, Dept Anaesthesia & Intens Care, London SW3 6NP, England
[2] Royal Brompton Hosp, Dept Thorac Surg, London SW3 6NP, England
关键词
free radicals; ischaemia reperfusion; lung injury; lung resection; oxidative damage; postpneumonectomy;
D O I
10.1183/09031936.98.11051028
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Postpneumonectomy pulmonary oedema (PPO) complicates a significant number of thoracic surgical procedures involving lung resection and in its extreme form is indistinguishable from the acute respiratory distress syndrome. This study investigated the possibility that ischaemia-reperfusion (I-R) injury contributes to PPO via the production of damaging reactive oxygen species. In a prospective, observational, comparative study, patients undergoing pneumonectomy, lobectomy, or wedge resection or open lung biopsy were investigated for perioperative changes in lung function indicative of lung injury and changes in plasma indices of oxidative damage. Significant percentage perioperative falls in plasma protein thiol levels (-17.9+/- 7.0% for pneumonectomy, -24.3+/-5.5% for two-lobe lobectomy and -10.2+/-2.2% for one-lobe lobectomy, p<0.05) and rises in plasma protein carbonyl levels (26.2+/-10.5% for pneumonectomy, p<0.05, 9.8+/-7.0% for two-lobe lobectomy and 5.0+/-3.7% for one-lobe lobectomy) were identified, but not in patients undergoing biopsy or wedge resection. Plasma myeloperoxidase levels rose in all groups, but not significantly. The carbon monoxide transfer coefficient (Kco) fell significantly in patients undergoing lobectomy (p<0.05) but not in those undergoing wedge resection, lung biopsy or pneumonectomy. Changes in markers of oxidative protein damage occurred in patients undergoing lung resection, although the gas transfer coefficient fell significantly only following lobectomy. Oxidative-damage occurs during pulmonary resection, although associated effects on gas exchange are seen only after lobectomy.
引用
收藏
页码:1028 / 1034
页数:7
相关论文
共 50 条
  • [1] Oxidative damage in patients undergoing pulmonary resection
    de la Asuncion, J. G.
    Garcia-Raimundo, M.
    Martinez-Hermosilla, M.
    Barber, G.
    Belda, J.
    [J]. EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2004, 21 : 126 - 126
  • [2] Prediction of postoperative pulmonary function in patients undergoing lung resection
    Lekkakou, A.
    Antypas, G.
    Chamalakis, G.
    Sklapani, P.
    Trakas, N.
    [J]. LUNG CANCER, 2007, 55 : S7 - S7
  • [3] PREDICTING POSTOPERATIVE PULMONARY FUNCTION IN PATIENTS UNDERGOING LUNG RESECTION
    Yatagai, Yohei
    Saito, Takefumi
    Umetsu, Yasuhiro
    Fukai, Shimao
    Hayashihara, Kenji
    Shiina, Masa
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2011, 6 (06) : S887 - S888
  • [4] PREDICTING POSTOPERATIVE PULMONARY-FUNCTION IN PATIENTS UNDERGOING LUNG RESECTION
    ZEIHER, BG
    GROSS, TJ
    KERN, JA
    LANZA, LA
    PETERSON, MW
    [J]. CHEST, 1995, 108 (01) : 68 - 72
  • [5] PREDICTING POSTOPERATIVE PULMONARY-FUNCTION IN PATIENTS UNDERGOING LUNG RESECTION
    ZEIHER, BG
    GROSS, TJ
    KERN, JA
    LANZA, LA
    PETERSON, MW
    [J]. CLINICAL RESEARCH, 1994, 42 (03): : A381 - A381
  • [6] Introducing new instruments for prediction of postoperative pulmonary complications in patients undergoing lung resection
    Brat, K.
    Cundrle, I., Jr.
    Mazur, A.
    Homolka, P.
    Chovanec, Z.
    Bratova, M.
    Mitas, L.
    Merta, Z.
    Svoboda, M.
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2022, 60
  • [7] Prediction of postoperative pulmonary reserve in lung resection patients
    Krishnakumar, R.
    Vijayalakshmi, K.
    Rangarajan, G. K.
    Vinodkumar, M. C.
    Krishnamurthy, A.
    [J]. POLISH JOURNAL OF RADIOLOGY, 2011, 76 (01) : 80 - 84
  • [8] Postoperative complications and perioperative management in patients on hemodialysis undergoing lung resection
    Watanabe, Yukio
    Hattori, Aritoshi
    Fukui, Mariko
    Matsunaga, Takeshi
    Takamochi, Kazuya
    Oh, Shiaki
    Suzuki, Kenji
    [J]. GENERAL THORACIC AND CARDIOVASCULAR SURGERY, 2021, 69 (03) : 478 - 486
  • [9] Postoperative complications and perioperative management in patients on hemodialysis undergoing lung resection
    Yukio Watanabe
    Aritoshi Hattori
    Mariko Fukui
    Takeshi Matsunaga
    Kazuya Takamochi
    Shiaki Oh
    Kenji Suzuki
    [J]. General Thoracic and Cardiovascular Surgery, 2021, 69 : 478 - 486
  • [10] Usefulness of chest X-ray planimetry for predicting postoperative pulmonary function for patients undergoing lung resection
    Ersoy, YM
    Ozvaran, MK
    Keus, L
    Alinsonorin, CY
    Jimenez, CA
    Morice, RC
    [J]. CHEST, 2003, 124 (04) : 76S - 76S