Synthesis of cytisine derivatives of coumarins

被引：19
|
作者：
Frasinyuk, M. S. [1 ]
Vinogradova, V. I.
Bondarenko, S. P. [2 ]
Khilya, V. P. [2 ]
机构：
[1] Natl Acad Sci Ukraine, Inst Bioorgan & Petr Chem, UA-02094 Kiev, Ukraine
[2] Taras Shevehenko Kiev Natl Univ, UA-01033 Kiev, Ukraine
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2007年 / 43卷 / 05期
关键词：
cytisine; 4-chloromethylcoumarin; alkylation; diisopropylethylamine;
D O I：
10.1007/s10600-007-0198-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New substituted 4-chloromethylcoumarins that were used as alkylating agents to modify cytisine were synthesized by Pechmann condensation. A series of 4-(12-cytisylmethyl)coumarins containing pharmacophores of the natural heterocycles coumarin and cytisine in a single molecule was prepared. The alkylation gave the best results if diisopropylethylamine was used as the base.
引用
收藏
页码：590 / 593
页数：4
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