Scrub typhus meningoencephalitis occurring during doxycycline therapy for Orientia tsutsugamushi

被引：13
|
作者：
Kim, Dong-Min [3 ,4 ]
Kim, Yoon Seong [3 ,4 ]
Cho, Hea-Young [2 ]
Lee, Yong-Bok [1 ]
机构：
[1] Chonnam Natl Univ, Coll Pharm, Inst Bioequivalence & Bridging Study, Kwangju 500757, South Korea
[2] Korea Food & Drug Adm, Clin Trials Management Div, Seoul, South Korea
[3] Chosun Univ, Coll Med, Dept Internal Med, Div Infect Dis, Kwangju, South Korea
[4] Chosun Univ, Coll Med, Res Ctr Resistant Cells, Kwangju, South Korea
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2011年 / 69卷 / 03期
关键词：
Scrub typhus; Doxycycline; Orientia tsutsugamushi; CEREBROSPINAL-FLUID; PENETRATION; DIAGNOSIS;
D O I：
10.1016/j.diagmicrobio.2010.10.005
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We report on a scrub typhus patient who contracted meningoencephalitis during doxycycline administration. This is the first case of scrub typhus in which doxycycline concentrations were measured in serum and cerebrospinal fluid. Clinicians should be alerted to the possibility that meningoencephalitis can occur because of inadequate maintenance of serum doxycycline level caused by antacids administered along with doxycycline. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：271 / 274
页数：4
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