Non-Hodgkin's Lymphomas, Version 3.2016 Featured Updates to the NCCN Guidelines

被引：92

作者：

Horwitz, Steven M. ^{[1
]}

Zelenetz, Andrew D. ^{[1
]}

Gordon, Leo I. ^{[2
]}

Wierda, William G. ^{[3
]}

Abramson, Jeremy S. ^{[4
]}

Advani, Ranjana H. ^{[5
]}

Andreadis, C. Babis ^{[6
]}

Bartlett, Nancy ^{[7
,8
]}

Byrd, John C. ^{[9
]}

Fayad, Luis E. ^{[3
]}

Fisher, Richard I. ^{[10
]}

Glenn, Martha J. ^{[11
]}

Habermann, Thomas M. ^{[12
]}

Harris, Nancy Lee ^{[4
]}

Hernandez-Ilizaliturri, Francisco ^{[13
]}

Hoppe, Richard T.

Kaminski, Mark S. ^{[14
]}

Kelsey, Christopher R. ^{[15
]}

Kim, Youn H. ^{[5
]}

Krivacic, Susan

LaCasce, Ann S. ^{[16
]}

Lunning, Matthew ^{[17
]}

Nademanee, Auayporn ^{[18
]}

Press, Oliver ^{[19
]}

Rabinovitch, Rachel ^{[20
]}

Reddy, Nishitha ^{[21
]}

Reid, Erin ^{[22
]}

Roberts, Kenneth ^{[23
]}

Saad, Ayman A. ^{[24
]}

Sokol, Lubomir ^{[25
]}

Swinnen, Lode J. ^{[26
]}

Vose, Julie M. ^{[17
]}

Yahalom, Joachim ^{[1
]}

Zafar, Nadeem ^{[27
]}

Dwyer, Mary ^{[28
]}

Sundar, Hema ^{[28
]}

Porcu, Pierluigi ^{[9
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[2] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Evanston, IL 60208 USA

[3] Univ Texas MD Anderson Canc Ctr, Houston, TX USA

[4] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[5] Stanford Canc Inst, Stanford, CA USA

[6] UCSF Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[7] Barnes Jewish Hosp, Siteman Canc Ctr, St Louis, MO 63110 USA

[8] Washington Univ, Sch Med, St Louis, MO 63130 USA

[9] Ohio State Univ, Ctr Comprehens Canc, James Canc Hosp & Solove Res Inst, Columbus, OH 43210 USA

[10] Fox Chase Canc Ctr, Philadelphia, PA USA

[11] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

[12] Mayo Clin, Ctr Canc, Rochester, MN USA

[13] Roswell Pk Canc Inst, Buffalo, NY USA

[14] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[15] Duke Canc Inst, Durham, NC USA

[16] Dana Farber Brigham & Womens Canc Ctr, Boston, MA USA

[17] Fred & Pamela Buffett Canc Ctr, Omaha, NE USA

[18] City Hope Comprehens Canc Ctr, Duarte, CA USA

[19] Fred Hutchinson Canc Res Ctr, Seattle Canc Care Alliance, Seattle, WA USA

[20] Univ Colorado, Ctr Canc, Boulder, CO 80309 USA

[21] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[22] UC San Diego Moores Canc Ctr, La Jolla, CA USA

[23] Yale Canc Ctr, Smilow Canc Hosp, New Haven, CT USA

[24] Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL USA

[25] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[26] Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

[27] Univ Tennessee, Hlth Sci Ctr, St Jude Childrens Res Hosp, Knoxville, TN 37996 USA

[28] Natl Comprehens Canc Network, Ft Washington, MD USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2016年 / 14卷 / 09期

关键词：

PERIPHERAL T-CELL; PHASE-II TRIAL; LONG-TERM REMISSIONS; BREAST IMPLANTS; SINGLE-AGENT; OPEN-LABEL; ALLOGENEIC TRANSPLANTATION; PROGNOSTIC-SIGNIFICANCE; CHEMOTHERAPY; GEMCITABINE;

D O I：

10.6004/jnccn.2016.0117

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Peripheral T-cell lymphomas (PTCLs) represent a relatively uncommon heterogeneous group of non-Hodgkin's lymphomas (NHLs) with an aggressive clinical course and poor prognosis. Anthracycline-based multiagent chemotherapy with or without radiation therapy followed by first-line consolidation with high-dose therapy followed by autologous stem cell rescue (HDT/ASCR) is the standard approach to most of the patients with newly diagnosed PTCL. Relapsed or refractory disease is managed with second-line systemic therapy followed by HDT/ASCR or allogeneic stem cell transplant, based on the patient's eligibility for transplant. In recent years, several newer agents have shown significant activity in patients with relapsed or refractory disease across all 4 subtypes of PTCL. These NCCN Guideline Insights highlight the important updates to the NCCN Guidelines for NHL, specific to the management of patients with relapsed or refractory PTCL.

引用

页码：1067 / 1079

页数：13

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