N-acetyl-6-sulfo-D-glucosamine as a promising mimic of N-acetyl neuraminic acid

被引：20
|
作者：
Sasaki, K
Nishida, Y
Uzawa, H
Kobayashi, K [1 ]
机构：
[1] Nagoya Univ, Grad Sch Engn, Dept Mol Design & Engn, Chikusa Ku, Nagoya, Aichi 4648603, Japan
[2] AIST, Tsukuba, Ibaraki 3058565, Japan
[3] JST, CREST, Kawaguchi, Saitama 3320012, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 17期
关键词：
D O I：
10.1016/S0960-894X(03)00611-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
6-sulfo-D-GlcNAc with a molecular geometry close to that of N-acetylneuraminic acid (Neu5Ac) was hypothesized to serve as a simple Neu5Ac mimic possessing high potential in biochemical and medicinal applications. The hypothesis was evidenced with a neuraminidase inhibition assay using p-nitrophenyl (pNP) 3-, 4-, and 6-sulfo-beta-D-GlcNAc (4, 5 and 2a) and 6-sulfo-beta-D-Glc 6, in which only pNP 6-sulfo-beta-D-GlcNAc 2a was found to show substantial activity. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2821 / 2823
页数：3
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