Association of the T45G and G276T polymorphisms in the adiponectin gene with PCOS: A meta-analysis

Adiponectin is the most abundant adipocytokine in human body and may play a role in the pathogenesis of polycystic ovary syndrome (PCOS). To clarify the conflicting data in the literature concerning the association between PCOS and two polymorphisms of the adiponectin gene, T45G and G276T, a meta-analysis was performed in this study. Literature search was conducted through PubMed, EMBASE and other relevant studies. Pooled odds ratios (OR) were estimated using fixed-effects (FE) models in codominant, recessive and dominant models. Sensitive analysis was performed by excluding invalid studies. Eight articles investigated the T45G polymorphism in PCOS, and five publications are associated with the G276T polymorphism in PCOS. Significant associations of adiponectin T45G polymorphism with PCOS were found in codominant (FEM: OR = 1.36, 95% CI: 1.12-1.65), recessive (FEM: OR = 2.02, 95% CI: 1.17-3.47) or dominant models (FEM: OR = 1.33, 95% CI: 1.06-1.67). For adiponectin G276T polymorphism, the OR and 95% CI are 0.81(0.68, 0.98), 0.74(0.51, 1.09) and 0.78 (0.61, 0.99) in codominant, dominant and recessive models, respectively. This study provides positive evidence for a causal relationship between the adiponectin gene and PCOS which needs to be further confirmed by further studies.