A mesenchymal chondrosarcoma with aberrant nuclear expression of STAT6: a potential diagnostic pitfall

被引：4
|
作者：
Broggi, Giuseppe [1 ]
Mazzucchelli, Manuel [1 ]
Covello, Renato [2 ]
Casini, Beatrice [2 ]
Broggi, Giuseppe Maria Vincenzo [3 ,4 ]
Salvatorelli, Lucia [1 ]
Magro, Gaetano [1 ]
机构：
[1] Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Anat Pathol, I-95123 Catania, Italy
[2] Regina Elena Natl Canc Inst IRCCS, Pathol Dept, I-00168 Rome, Italy
[3] Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Neurol Surg, Policlin Rodolico San Marco Univ Hosp, I-95123 Catania, Italy
[4] Univ Catania, Interdisciplinary Res Ctr Diag & Therapy Brain Tu, I-95123 Catania, Italy
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2022年 / 232卷
关键词：
Mesenchymal chondrosarcoma; STAT6; HEY1-NCOA2 fusion gene; NAB2-STAT6 fusion gene; Diagnostic pitfall; SOLITARY FIBROUS TUMOR; IMMUNOHISTOCHEMISTRY; FUSION;
D O I：
10.1016/j.prp.2022.153803
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
STAT6 is usually considered to be a very sensitive and specific immunomarker for diagnosis of solitary fibrous tumor (SFT), being a surrogate of the NAB2-STAT6 fusion gene identified in most cases of this tumor. STAT6 expression has also been reported in rare cases of other soft tissue tumors, such as low-grade fibromyxoid sar -coma, myxoid/round cell liposarcoma, dedifferentiated liposarcoma and deep fibrous histiocytoma. The aim of this study was to report, for the first time, a case of mesenchymal chondrosarcoma showing diffuse aberrant immunohistochemical expression of STAT6. Molecular biology, showing the HEY1-NCOA2 fusion gene, was crucial to rule out SFT.
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页数：4
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