Antibody response to outer membrane proteins in Shigella dysenteriae type 1 infection with special reference to appearance of murine antibodies

被引：0
|
作者：
Chakrabarti, S [1 ]
Sinha, AK [1 ]
机构：
[1] NATL INST CHOLERA & ENTER DIS, DIV IMMUNOL, CALCUTTA 700010, W BENGAL, INDIA
来源：
INDIAN JOURNAL OF MEDICAL RESEARCH | 1996年 / 104卷
关键词：
antibody response; ELISA; immunodominance; outer membrane proteins; Shigella dysenteriae 1;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In shigellosis, the protective immune mechanism is not well established. The bacterial outer membrane proteins (OMPs) may have a role in the induction of immunity due to their outwardly location. The serum antibody response of S. dysenteriae type 1 infected patients against OMPs was assessed by enzyme linked immunosorbent assay (ELISA). A striking elevation of serum IgG response,vas noted during the convalescent phase. Murine antiserum directed against S. dysenteriae 1 OMPs was found to be highly cross reactive with the OMPs isolated from heterologous species, A major antigenic OMP was partially purified and showed distinct immunodominance in ELISA, These observations suggest that the specific component may have some immunoprophylactic potential.
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页码：142 / 147
页数：6
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