Clinical risk factors for primary graft failure following lung transplantation

被引:213
|
作者
Christie, JD
Kotloff, RM
Pochettino, A
Arcasoy, SM
Rosengard, BR
Landis, JR
Kimmel, SE
机构
[1] Univ Penn, Sch Med, Div Pulm Allergy & Crit Care Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA
[4] Columbia Univ, Coll Phys & Surg, Div Pulm & Crit Care Med, Dept Med, New York, NY 10027 USA
[5] Univ Penn, Sch Med, Dept Surg, Div Thorac Surg, Philadelphia, PA 19104 USA
关键词
acute lung injury; gender; lung transplantation; organ donation; pulmonary hypertension; race; reperfusion injury;
D O I
10.1378/chest.124.4.1232
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Study objectives: Primary graft failure (PGF) is. a devastating acute lung injury syndrome following lung transplantation. We sought to identify donor, recipient, and operative risk factors for its development. Design: We conducted a cohort study of 255 consecutive lung transplant procedures performed between October 1991 and July 2000. We defined PGF as follows: (1) diffuse alveolar opacities exclusively involving allograft(s) and developing within 72 h of transplant, (2) a ratio of Pao(2) to fraction of inspired oxygen < 200 beyond 48 h postoperatively, and (3) no other secondary cause of graft dysfunction identified. Risk factors were assessed individually and adjusted for confounding using multivairiable logistic regression models. Setting: Tertiary-care academic medical center. Results: The overall incidence was 11.8% (95% confidence interval [CI], 7.9 to 15.9). Following multivariable analysis, the risk factors independently associated with development of PGF were as follows: a recipient diagnosis of primary pulmonary hypertension (PPH; adjusted odds ratio [OR], 4.52; 95% CI, 1.29 to 15.9; p = 0.018), donor female gender (adjusted OR, 4.11; 95% CI, 1.17 to 14.4; p = 0.027), donor African-American race (adjusted OR, 5.56; 95% CI, 1.57 to 19.8; p = 0.008), and donor age < 21 years (adjusted OR, 4.06; 95% CI, 1.34 to 12.3; p = 0.013) and > 45 years (adjusted OR, 6.79; 95% CI, 1.61 to 28.5; p = 0.009). Conclusions: Recipient diagnosis of PPH, donor African-American race, donor female gender, and donor age are independently and strongly associated with development of PGF.
引用
收藏
页码:1232 / 1241
页数:10
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