Kinetics and mechanism of deoximation of benzophenone oximes by N-chloro-3-methyl-2,6-diphenylpiperidin-4-one

Deoximation of benzophenone oxime (BPO) and several of its para-substituted derivatives by N-chloro-3-methyl-2,6-diphenylpiperidin-4-one (NCP) yields respective ketones. The stoichiometry of the reaction was found to be 1:1 and the order with respect to [substrate] and [oxidant] was found to be one each. Increasing [H+] and [Cl-] increases the rate of the reaction. Increasing the percentage of ethanol decreases the rate of the reaction. The mechanistic pathways of the reaction have been discussed and substantiated through multiparameter correlation analysis of the substituted effect.