Generation and cardiac differentiation of an induced pluripotent stem cell line from a patient with arrhythmia-induced cardiomyopathy

被引：0
|
作者：
Rebs, Sabine [1 ,2 ]
Beier, Jakob [1 ,2 ]
Argyriou, Loukas [2 ,3 ]
Schill, Tillmann [4 ]
Hasenfuss, Gerd [1 ,2 ]
Vollmann, Dirk [5 ]
Sossalla, Samuel [1 ,2 ,6 ]
Streckfuss-Boemeke, Katrin [1 ,2 ]
机构：
[1] Univ Med Ctr Goettingen, Clin Cardiol & Pneumol, Robert Koch Str 40, D-37075 Gottingen, Germany
[2] DZHK, German Ctr Cardiovasc Res, Partner Site Goettingen, Gottingen, Germany
[3] Univ Med Ctr Goettingen, Inst Human Genet, Gottingen, Germany
[4] Univ Med Ctr Goettingen, Dept Dermatol Venereol & Allergol, Gottingen, Germany
[5] Herz & Gefasszentrum Goettingen, Gottingen, Germany
[6] Univ Med Ctr Regensburg, Clin & Polyclin Internal Med 2, Regensburg, Germany
来源：
STEM CELL RESEARCH | 2021年 / 53卷
关键词：
D O I：
10.1016/j.scr.2021.102263
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Arrhythmia-induced cardiomyopathy (AIC) is characterized by left-ventricular systolic dysfunction caused by persistent arrhythmia. To date, genetic or pathological drivers causing AIC remain unknown. Here, we generated induced pluripotent stem cells (iPSCs) from an AIC patient. The AIC-iPSCs exhibited full pluripotency and differentiation characteristics and maintained a normal karyotype after reprogramming. The AIC-iPSCs differentiated into functional beating AIC-iPSCcardiomyocytes (CMs), which represents the cell-type of interest to study molecular, genetic and functional aspects of AIC.
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页数：5
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